| 2-(aminoacylamino)benzophenones: farnesyltransferase inhibition and antimalarial activity. | |
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MedLine Citation:
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PMID: 16222868 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The use of amino acids as acyl substitutents at the 2-amino group of our benzophenone core structure yielded compounds with mainly good to moderate farnesyltransferase inhibitory and moderate antimalarial activity. However, these farnesyltransferase inhibitors display some degree of selectivity towards malarial parasites since there was no cytotoxic activity observed at 70-80 microM. |
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Authors:
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K Kettler; J Wiesner; K Fucik; J Sakowski; R Ortmann; H M Dahse; H Jomaa; M Schlitzer |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Die Pharmazie Volume: 60 ISSN: 0031-7144 ISO Abbreviation: Pharmazie Publication Date: 2005 Sep |
Date Detail:
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Created Date: 2005-10-14 Completed Date: 2005-11-30 Revised Date: 2007-01-29 |
Medline Journal Info:
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Nlm Unique ID: 9800766 Medline TA: Pharmazie Country: Germany |
Other Details:
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Languages: eng Pagination: 677-82 Citation Subset: IM |
Affiliation:
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Department für Pharmazie, Zentrum für Pharmaforschung, Ludwig-Maximilians-Universität, München. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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chemistry Animals Antimalarials / chemical synthesis*, pharmacology* Benzophenones / chemical synthesis*, pharmacology* Enzyme Inhibitors / chemical synthesis*, pharmacology* Erythrocytes / parasitology Escherichia coli / drug effects, enzymology Hela Cells Humans Magnetic Resonance Spectroscopy Plasmodium falciparum / drug effects, growth & development Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Antimalarials; 0/Benzophenones; 0/Enzyme Inhibitors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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