Document Detail


MedLine Citation:
PMID:  3478154     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Thirty-eight patients with adult acute lymphoblastic leukemia (ALL) or non-Hodgkin's lymphoma (NHL) were treated intravenously with (2"-R)-4'-o-Tetrahydropyranyladriamycin (THP) at a dose of 10 mg/m2 for 5 consecutive days. Seven complete and 15 partial responses were observed in 35 evaluable patients (overall response rate, 62.8%). Both antitumor activity and antitumor spectrum were similar to those for doxorubicin. Since the patients who had had chemotherapy previously, including other kinds of anthracycline, responded rather poorly to THP, cross-resistance between THP and other anthracyclines may be present. Leukopenia and thrombocytopenia were dose-limiting factors. Nausea and vomiting episodes were mild, and epilation was also minimal. Although the observation period was short and a cumulative dose was not large enough to evaluate cardiotoxicity, there were no abnormal EKG changes or clinical signs of cardiotoxicity in this study. THP is a potent antitumor agent in the treatment of lymphoid malignancies.
Authors:
T Takagi; M Oguro
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cancer chemotherapy and pharmacology     Volume:  20     ISSN:  0344-5704     ISO Abbreviation:  Cancer Chemother. Pharmacol.     Publication Date:  1987  
Date Detail:
Created Date:  1987-11-25     Completed Date:  1987-11-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7806519     Medline TA:  Cancer Chemother Pharmacol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  151-4     Citation Subset:  IM    
Affiliation:
Division of Hematology-Chemotherapy, Chiba Cancer Center Hospital, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Doxorubicin / adverse effects,  analogs & derivatives*,  therapeutic use
Female
Humans
Leukemia, Lymphoid / drug therapy*,  pathology
Lymphoma, Non-Hodgkin / drug therapy*,  pathology
Male
Middle Aged
Retrospective Studies
Chemical
Reg. No./Substance:
23214-92-8/Doxorubicin; 72496-41-4/pirarubicin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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