Document Detail

2-Pyridone and Derivatives: Gas Phase Acidity, Proton Affinity, Tautomer Preference and Leaving Group Ability.
MedLine Citation:
PMID:  22112009     Owner:  NLM     Status:  Publisher    
The fundamental properties of the parent and substituted 2-pyridones (2-pyridone, 3-chloro-2-pyridone, 3-formyl-2-pyridone) have been examined in the gas phase using computational and experimental mass spectrometry methods. Newly measured acidities and proton affinities are reported and used to ascertain tautomer preference. These particular substrates (as well as additional 3-substituted pyridones) were chosen in order to examine the correlation between leaving group ability and acidity for moieties that allow resonance delocalization versus those that do not, which is discussed herein.
Anna Zhachkina Michelson; Aaron Petronico; Jeehiun K Lee
Related Documents :
15807619 - Substitution and condensation reactions with poly(anilineboronic acid): reactivity and ...
12234209 - Solid acids for green chemistry.
6266319 - The catalytic function of active site amino acid side chains in well-characterized enzy...
20714469 - Kinetic studies of the heterogeneous oxidation of maleic and fumaric acid aerosols by o...
18183999 - Allylations of chelated enolates using dienyl substrates.
15054249 - Predicted effects of mineral neutralization and bisulfate formation on hydrogen ion con...
16659089 - Action of nalidixic acid on chloroplast replication in euglena gracilis.
23471869 - Surface-mediated nucleic acid delivery by lipoplexes prepared in microwell arrays.
7024149 - Parameters influencing the in vitro growth of mycobacterium lepraemurium.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-23
Journal Detail:
Title:  The Journal of organic chemistry     Volume:  -     ISSN:  1520-6904     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985193R     Medline TA:  J Org Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  REFOCUS Trial: protocol for a cluster randomised controlled trial of a pro-recovery intervention wit...
Next Document:  Visible-light Driven Photoelectrochemical Water Oxidation on Nitrogen-modified TiO2 Nanowires.