| 2-Oxo-2H-benzo[h]benzopyran as a new light sensitive protecting group for neurotransmitter amino acids. | |
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MedLine Citation:
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PMID: 19908122 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Aiming at the development of new benzopyran-based photocleavable protecting groups, novel chloromethylated and hydroxymethylated 2-oxo-2H-benzo[h]benzopyran derivatives bearing a methoxy substituent were designed and used in the synthesis of a series of fluorescent bioconjugates, by linking through an ester or urethane bond to several model neurotransmitter amino acids (glycine, alanine, beta-alanine and gamma-aminobutyric acid, GABA). The resulting fluorescent bioconjugates with emission in the visible range and high fluorescent quantum yields, were subjected to photocleavage reaction in methanol/HEPES buffer (80:20) solution at different wavelengths of irradiation (250, 300, 350 and 419 nm) and photocleavage kinetic data were obtained. |
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Authors:
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Ana M S Soares; Susana P G Costa; M Sameiro T Gonçalves |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-11-12 |
Journal Detail:
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Title: Amino acids Volume: 39 ISSN: 1438-2199 ISO Abbreviation: Amino Acids Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-09 Completed Date: 2010-09-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9200312 Medline TA: Amino Acids Country: Austria |
Other Details:
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Languages: eng Pagination: 121-33 Citation Subset: IM |
Affiliation:
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Centro de Química, Universidade do Minho, Campus de Gualtar, 4710-057, Braga, Portugal. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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chemical synthesis,
chemistry* Coumarins / chemical synthesis, chemistry* Fluorescence Fluorescent Dyes / chemistry* Light* Molecular Structure Neurotransmitter Agents / chemical synthesis, chemistry* Quantum Theory Stereoisomerism |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Coumarins; 0/Fluorescent Dyes; 0/Neurotransmitter Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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