| 2-Nitrosoimino-3,6-dihydro-2H-1,3,4-thiadiazines with antiplatelet and antithrombotic properties. | |
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MedLine Citation:
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PMID: 9879566 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The successful synthesis of 17 nitrosimines of 2 H-1,3,4-thiadiazines is reported. They are best characterized by their electronic spectra (lambda max = 504-522 nm). Some of the compounds were able to inhibit the aggregation of blood platelets in the Born-test (inducer collagen). The most active compound was the 3-nonyl-5-phenyl-derivative 10c which showed an IC50 = 6.5 mumol.l-1. In mesenteric arterioles of rats after p.o. administration (60 mg/kg) a 13% inhibition of thrombus formation is observed. The reason for the rather small effects is the high chemical stability of the title compounds and the fact that decomposition occurs mainly by the evolution of molecular nitrogen. Only small yields of NO are formed. |
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Authors:
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K Rehse; U Brümmer; E Unsöld |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Die Pharmazie Volume: 53 ISSN: 0031-7144 ISO Abbreviation: Pharmazie Publication Date: 1998 Dec |
Date Detail:
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Created Date: 1999-04-01 Completed Date: 1999-04-01 Revised Date: 2007-01-29 |
Medline Journal Info:
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Nlm Unique ID: 9800766 Medline TA: Pharmazie Country: GERMANY |
Other Details:
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Languages: eng Pagination: 820-4 Citation Subset: IM |
Affiliation:
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Institut für Pharmazie, Freie Universität Berlin, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Capillaries / drug effects Fibrinolytic Agents / chemical synthesis*, chemistry, pharmacology Mesentery / blood supply Nitrosamines / chemical synthesis*, chemistry, pharmacology Platelet Aggregation / drug effects Platelet Aggregation Inhibitors / chemical synthesis*, chemistry, pharmacology Rabbits Rats Structure-Activity Relationship Thiadiazines / chemical synthesis*, chemistry, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Fibrinolytic Agents; 0/N-nitroso-3-nonyl-5-phenyl-3,6-dihydro-2H-1,3,4-thiadiazine-2-imine; 0/Nitrosamines; 0/Platelet Aggregation Inhibitors; 0/Thiadiazines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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