Document Detail


2-Nitrobenzaldehyde: a convenient UV-A and UV-B chemical actinometer for drug photostability testing.
MedLine Citation:
PMID:  11130196     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report the development of a new 'photochemical titration' actinometric method for measurement of UV-B (290-320 nm) and UV-A (320-400 nm) light dose during drug photostability testing. It is based upon photolysis of aqueous 2-nitrobenzaldehyde solution, a well-characterized reaction that has been previously demonstrated to be useful as an accurate and reliable actinometric method. Our new method can be performed by a chemical technician using only common reagents. It has been developed for use with xenon arc lamp illumination chambers which are commonly employed for drug photostability testing, but can be readily modified for use with the other illumination sources.
Authors:
J M Allen; S K Allen; S W Baertschi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of pharmaceutical and biomedical analysis     Volume:  24     ISSN:  0731-7085     ISO Abbreviation:  J Pharm Biomed Anal     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2000-12-20     Completed Date:  2001-03-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8309336     Medline TA:  J Pharm Biomed Anal     Country:  England    
Other Details:
Languages:  eng     Pagination:  167-78     Citation Subset:  IM    
Affiliation:
Department of Chemistry, Indiana State University, Terre Haute, IN 47809, USA. challen@scifac.indstate.edu
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MeSH Terms
Descriptor/Qualifier:
Benzaldehydes / chemistry*
Drug Stability*
Pharmaceutical Preparations / radiation effects
Photochemistry
Ultraviolet Rays*
Chemical
Reg. No./Substance:
0/Benzaldehydes; 0/Pharmaceutical Preparations; 552-89-6/2-nitrobenzaldehyde

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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