Document Detail

A 2-Mb YAC/BAC-based physical map of the ovum mutant (Om) locus region on mouse chromosome 11.
MedLine Citation:
PMID:  10995569     Owner:  NLM     Status:  MEDLINE    
The embryonic lethal phenotype observed when DDK females are crossed with males from other strains results from a deleterious interaction between the egg cytoplasm and the paternal pronucleus soon after fertilization. We have previously mapped the Om locus responsible for this phenotype, called the DDK syndrome, to an approximately 2-cM region of chromosome 11. Here, we report the generation of a physical map of 28 yeast and bacterial artificial chromosome clones encompassing the entire genetic interval containing the Om locus. This contig, spanning approximately 2 Mb, was used to map precisely genes and genetic markers of the region. We determined the maximum physical interval for Om to be 1400 kb. In addition, 11 members of the Scya gene family were found to be organized into two clusters at the borders of the Om region. Two other genes (Rad51l3 and Schlafen 2) and one EST (D11Wsu78e) were also mapped in the Om region. This integrated map provides support for the identification of additional candidate genes for the DDK syndrome.
M Cohen-Tannoudji; S Vandormael-Pournin; S Le Bras; F Coumailleau; C Babinet; P Baldacci
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Genomics     Volume:  68     ISSN:  0888-7543     ISO Abbreviation:  Genomics     Publication Date:  2000 Sep 
Date Detail:
Created Date:  2000-11-16     Completed Date:  2000-11-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8800135     Medline TA:  Genomics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  273-82     Citation Subset:  IM    
Copyright Information:
Copyright 2000 Academic Press.
Unité de Biologie du Développement, CNRS URA 1960, Institut Pasteur, 25 rue du Dr. Roux, Paris Cedex 15, 75724, France.
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MeSH Terms
Chromosome Mapping*
Chromosomes, Artificial, Bacterial
Chromosomes, Artificial, Yeast
Crosses, Genetic
Genetic Markers
Genomic Imprinting*
Infertility, Female / genetics*
Mice, Inbred BALB C / genetics
Mice, Inbred C57BL / genetics
Mice, Inbred Strains / genetics*
Sequence Tagged Sites
Reg. No./Substance:
0/Genetic Markers

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