Document Detail


2-Hydroxyphenacyl azoles and related azolium derivatives as antifungal agents.
MedLine Citation:
PMID:  18032039     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
2-Hydroxyphenacyl azole and 2-hydroxyphenacyl azolium compounds have been described as a new class of azole antifungals. Most target compounds showed significant in vitro antifungal activities against tested fungi (Candida albicans, Saccharomyces cerevisiae, Aspergillus niger, and Microsporum gypseum) with low MICs values included in the range of 0.25-32 microg/mL comparable to reference drug fluconazole. The most active compounds were also assessed for their cytotoxicity using MTT colorimetric assay on normal mouse fibroblast (NIH/3T3) cells. The results of antifungal activity and toxicity tests indicated that these compounds display antifungal activity at non-cytotoxic concentrations.
Authors:
Saeed Emami; Alireza Foroumadi; Mehraban Falahati; Ensieh Lotfali; Saeed Rajabalian; Soltan-Ahmed Ebrahimi; Shirin Farahyar; Abbas Shafiee
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Publication Detail:
Type:  Journal Article     Date:  2007-11-04
Journal Detail:
Title:  Bioorganic & medicinal chemistry letters     Volume:  18     ISSN:  1464-3405     ISO Abbreviation:  Bioorg. Med. Chem. Lett.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-01-09     Completed Date:  2008-02-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107377     Medline TA:  Bioorg Med Chem Lett     Country:  England    
Other Details:
Languages:  eng     Pagination:  141-6     Citation Subset:  IM    
Affiliation:
Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari 48175, Iran. sd_emami@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Acetophenones / chemical synthesis,  chemistry*,  pharmacology*
Antifungal Agents / chemical synthesis,  chemistry*,  pharmacology*
Azoles / chemical synthesis,  chemistry*,  pharmacology*
Microbial Sensitivity Tests
Structure-Activity Relationship
Chemical
Reg. No./Substance:
0/Acetophenones; 0/Antifungal Agents; 0/Azoles

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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