Document Detail


2-Deoxy-D-glucose-induced hypothermia: thermoregulatory pathways in rat.
MedLine Citation:
PMID:  7435598     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
2-Deoxy-D-glucose (2-DG) elicits significant and prolonged hypothermia in a variety of animals when administered either peripherally or centrally. From our current studies it would appear that, in high concentrations (250 mg/kg or more, ip), 2-DG can act directly on peripheral tissues in the rat by competitively interfering with glucose metabolism and consequently with normal heat producing mechanisms. When a low concentration of 2-DG (20 micrograms) is injected centrally, the ensuing glucopenia results in vagal stimulation and subsequent diminution of peripheral heat production. Vagal involvement is concluded from studies with atropine, which demonstrated total inhibition of the usual 2-DG depression of body temperature by administration to the ventral premammillary nucleus (PMV), a site that is normally extremely sensitive to this analog of glucose. Additionally, from studies with PMV-lesioned rats, it was concluded that an intact nucleus is necessary for thermoregulation in a normal, a hot, or a cold environment.
Authors:
T Shiraishi; M Mager
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of physiology     Volume:  239     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1980 Sep 
Date Detail:
Created Date:  1981-01-26     Completed Date:  1981-01-26     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R270-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Temperature Regulation / drug effects*
Deoxy Sugars / administration & dosage*
Deoxyglucose / administration & dosage*,  pharmacology
Dose-Response Relationship, Drug
Hypothalamus / physiology*
Injections, Intraperitoneal
Male
Oxygen Consumption
Rats
Chemical
Reg. No./Substance:
0/Deoxy Sugars; 154-17-6/Deoxyglucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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