Document Detail

2-Deoxy-D-glucose, but not mercaptoacetate, increases food intake in decerebrate rats.
MedLine Citation:
PMID:  19494173     Owner:  NLM     Status:  MEDLINE    
We examined food intake in chronically maintained decerebrate rats in response to two antimetabolic drugs known to stimulate food intake, 2-mercaptoacetate (MA) and 2-deoxy-D-glucose (2DG). MA reduces fatty acid oxidation, and 2DG reduces glucose utilization. Because previous work has shown that insulin-induced hypoglycemia increases food intake in decerebrate rats, we predicted that 2DG would have this same effect. MA-induced feeding requires vagal sensory neurons that terminate in the hindbrain. Cholecystokinin-induced suppression of feeding, which likewise requires vagal sensory neurons, has been shown to suppress food intake in decerebrate rats. Therefore, we predicted that MA's effects on feeding would also persist in decerebrate rats. In our experiments, the test diet (40% milk, diluted with water) was infused intraorally through a chronic cheek fistula. We found that sham controls consumed 258% and 230% of their baseline milk intake in response to 2DG and MA, respectively. Decerebrates consumed 239% of their baseline milk intake in response to 2DG, but did not increase their intake in response to MA. Because decerebration separates the hindbrain from the forebrain, these results indicate that 2DG-induced glucoprivation is capable of acting within the hindbrain to activate fundamental reflex circuitry for consummatory feeding responses, as shown previously for hypoglycemia. In contrast, MA affects food consumption only after forebrain processing of MA-induced vagal afferent signals and in the presence of intact ascending and descending neural pathways.
Rebecca A Darling; Sue Ritter
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2009-06-03
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  297     ISSN:  1522-1490     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-22     Completed Date:  2009-08-18     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  R382-6     Citation Subset:  IM    
Programs in Neuroscience, Washington State Univ., Pullman, WA, USA.
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MeSH Terms
Antimetabolites / pharmacology
Appetite Regulation / physiology
Decerebrate State / physiopathology*
Deoxyglucose / pharmacology*
Eating / drug effects*
Prosencephalon / surgery
Rats, Sprague-Dawley
Rhombencephalon / surgery
Thioglycolates / pharmacology
Grant Support
Reg. No./Substance:
0/Antimetabolites; 0/Thioglycolates; 154-17-6/Deoxyglucose; 7857H94KHM/2-mercaptoacetate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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