Document Detail


2-Chlorobenzylmercapturic acid, a metabolite of the riot control agent 2-chlorobenzylidene malononitrile (CS) in the rat.
MedLine Citation:
PMID:  6418119     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Adult male Wistar rats administered i.p. with 2-chlorobenzylidene malononitrile (CS) excreted one mercapturic acid in urine. The amount of mercapturic acid determined gaschromatographically was about 4% of the dose (0.07 mmol/kg, n = 12). The structure of the mercapturic acid methylester was identified by t.l.c. and confirmed by synthesis and mass-spectrography. The acid appeared to be 2-chlorobenzylmercapturic acid [N-acetyl-S-(2-chlorobenzyl)-L-cysteine]. CS and some of its metabolites were also tested in the Ames Salmonella/microsome assay. Both mutagenic and toxic effects were measured with strain TA 100 as the indicator organism. No mutagenic effects were found with any of the tested substances. At dosages of CS, higher than 1,000 micrograms/plate a bacteriotoxicity was revealed.
Authors:
E C Rietveld; L P Delbressine; T H Waegemaekers; F Seutter-Berlage
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of toxicology     Volume:  54     ISSN:  0340-5761     ISO Abbreviation:  Arch. Toxicol.     Publication Date:  1983 Oct 
Date Detail:
Created Date:  1984-01-27     Completed Date:  1984-01-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0417615     Medline TA:  Arch Toxicol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  139-44     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acetylcysteine / analogs & derivatives,  toxicity,  urine
Animals
Chromatography, Gas
Male
Mass Spectrometry
Mutagenicity Tests
Mutagens
Nitriles / metabolism*
Rats
Rats, Inbred Strains
Salmonella / genetics
o-Chlorobenzylidenemalonitrile / metabolism*,  toxicity
Chemical
Reg. No./Substance:
0/Mutagens; 0/Nitriles; 2698-41-1/o-Chlorobenzylidenemalonitrile; 40379-72-4/2-chlorobenzylmercapturic acid; 616-91-1/Acetylcysteine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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