Document Detail

2-Butoxyethanol enhances the adherence of red blood cells.
MedLine Citation:
PMID:  12756519     Owner:  NLM     Status:  MEDLINE    
We recently presented a unique, chemically-induced rat model of hemolytic anemia and disseminated thrombosis. In this 2-butoxyethanol (BE)-induced model the organs developing infarction are comparable to those seen in human diseases, characterized by hemolysis and thrombosis (e.g., thalassemia, sickle-cell disease, paroxysmal nocturnal hemoglobinuria, disseminated intravascular coagulation, thrombotic thrombocytopenic purpura, and hemolytic uremic syndrome). Red blood cells (RBCs) have special flow properties, namely, self-aggregability, deformability, and potential adherence to endothelial cells (ECs) of the blood vessel wall, which are essential for adequate blood flow and tissue perfusion; their alteration facilitates circulatory disorders. To examine the possible contribution of alterations in RBC flow properties to the observed thrombosis in the present investigation we determined the BE-induced changes in adherence, aggregability, and deformability of RBCs from male and female Fischer F344 rats exposed to two, three, or four daily doses of BE at 250 mg BE/kg body weight. Control animals were treated with the vehicle alone. Blood was taken on days 2, 3, 4, and 29. The administration of BE did not affect the RBCs aggregability but markedly enhanced their adherence to extracellular matrix; such enhancement was correlated with adherence to cultured ECs. RBC/EC interaction has been shown to be a potent catalyst of vascular occlusion in hemolytic hemoglobinopathies; thus the enhanced RBC adherence to EC is a likely mechanism by which thrombosis and organ infarct are induced in BE-treated rats.
Alexander Koshkaryev; Gregory Barshtein; Abraham Nyska; Nathan Ezov; Tal Levin-Harrus; Shay Shabat; Meir Nyska; Meir Redlich; Felix Tsipis; Saul Yedgar
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2003-05-20
Journal Detail:
Title:  Archives of toxicology     Volume:  77     ISSN:  0340-5761     ISO Abbreviation:  Arch. Toxicol.     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-08-25     Completed Date:  2004-07-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0417615     Medline TA:  Arch Toxicol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  465-9     Citation Subset:  IM    
Department of Biochemistry, Hadassah Medical School, Hebrew University, Jerusalem, Israel.
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MeSH Terms
Administration, Oral
Cell Adhesion / drug effects
Dose-Response Relationship, Drug
Endothelium, Vascular / drug effects
Erythrocyte Aggregation / drug effects
Erythrocyte Deformability / drug effects
Erythrocytes / drug effects*,  physiology
Ethylene Glycols / administration & dosage,  toxicity*
Rats, Inbred F344
Reg. No./Substance:
0/Ethylene Glycols; 111-76-2/n-butoxyethanol

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