Document Detail

Intermedin/adrenomedullin 2 is associated with implantation and placentation via trophoblast invasion in human pregnancy.
MedLine Citation:
PMID:  23337723     Owner:  NLM     Status:  MEDLINE    
RATIONALE: Intermedin (IMD) is a novel peptide expressed in trophoblast cells in human placenta and enhances the invasion, migration, and human leukocyte antigen class I, G (HLA-G) expression in first-trimester HTR-8SV/neo cells. We recently reported that infusion of IMD antagonist in pregnant rats is detrimental to pregnancy outcome, resulting in impaired fetoplacental growth and deformed placental vasculature.
OBJECTIVE: This study was undertaken to assess expression of IMD and its involvement in human implantation and early placentation and assess whether its expression is altered in spontaneous abortion.
FINDINGS AND CONCLUSIONS: We demonstrate for the first time that IMD is present in day 5 embryonic secretome; villous and decidual expression of IMD is higher at 6-8 weeks after a decline as gestation advances toward the second trimester; first-trimester spontaneous abortion is associated with a lower expression of IMD in serum, villi, and decidua; IMD stimulates the invasive capacity of first-trimester primary Extravillous cytotrophoblast cells; and IMD decreases elevated levels of tumor suppressor Kangia-1 in decidual explants from first-trimester spontaneous abortion. In conclusion, this study is the first to demonstrate a potential involvement of IMD in human embryo implantation and placental development via regulation of trophoblast invasion at the maternal-fetal interface and suggests a physiological role for this novel peptide in establishment of human pregnancy.
Dara Havemann; Meena Balakrishnan; Mostafa Borahay; Regan Theiler; Kristofer Jennings; Janice Endsley; John Phelps; Gary D V Hankins; Chandra Yallampalli; Madhu Chauhan
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2013-01-21
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  98     ISSN:  1945-7197     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-07     Completed Date:  2013-04-10     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  695-703     Citation Subset:  AIM; IM    
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MeSH Terms
Blastocyst / physiology
Embryo Implantation / physiology*
Peptide Hormones / physiology*
Placenta / physiology*
Placentation / physiology*
Pregnancy Trimester, First
Trophoblasts / physiology*
Grant Support
Reg. No./Substance:
0/ADM2 protein, human; 0/Peptide Hormones

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