Document Detail


2-Aryloxymethylmorpholine histamine H(3) antagonists.
MedLine Citation:
PMID:  18922693     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The synthesis and biological activity of a new series of 2-aryloxymethylmorpholine histamine H(3) antagonists is described. The new compounds are high affinity histamine H(3) ligands that penetrate the CNS and occupy the histamine H(3) receptor in rat brain.
Authors:
Michael A Letavic; John M Keith; Kiev S Ly; Pascal Bonaventure; Mark A Feinstein; Brian Lord; Kirsten L Miller; S Timothy Motley; Diane Nepomuceno; Steven W Sutton; Nicholas I Carruthers
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Publication Detail:
Type:  Journal Article     Date:  2008-09-24
Journal Detail:
Title:  Bioorganic & medicinal chemistry letters     Volume:  18     ISSN:  1464-3405     ISO Abbreviation:  Bioorg. Med. Chem. Lett.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2009-10-30     Completed Date:  2009-12-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107377     Medline TA:  Bioorg Med Chem Lett     Country:  England    
Other Details:
Languages:  eng     Pagination:  5796-9     Citation Subset:  IM    
Affiliation:
Johnson & Johnson Pharmaceutical Research & Development L.L.C., San Diego, CA 92121-1126, USA. mletavic@its.jnj.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / metabolism
Histamine H3 Antagonists / chemical synthesis,  pharmacokinetics,  pharmacology*
Morpholines / chemical synthesis,  pharmacokinetics,  pharmacology*
Rats
Chemical
Reg. No./Substance:
0/Histamine H3 Antagonists; 0/Morpholines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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