| 2-Aryl-2-nitroacetates as central precursors to aryl nitromethanes, α-ketoesters, and α-amino acids. | |
MedLine Citation:
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PMID: 23245626 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nitroarylacetates are useful small molecular building blocks that act as precursors to α-ketoesters and aryl nitromethanes as well as α-amino acids. Methods were developed that produce each of these compound types in good yields. Two different conditions for decarboxylation are discussed for substrates with neutral and electron-poor aryl groups versus electron-rich aryl groups. For formation of the α-ketoesters, new mild conditions for the Nef disproportionation were identified. |
Authors:
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Alison E Metz; Marisa C Kozlowski |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2013-01-02 |
Journal Detail:
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Title: The Journal of organic chemistry Volume: 78 ISSN: 1520-6904 ISO Abbreviation: J. Org. Chem. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-01-18 Completed Date: 2013-09-10 Revised Date: 2014-06-24 |
Medline Journal Info:
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Nlm Unique ID: 2985193R Medline TA: J Org Chem Country: United States |
Other Details:
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Languages: eng Pagination: 717-22 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetates
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chemistry* Amino Acids / chemistry* Catalysis Esters Molecular Structure Palladium / chemistry* Stereoisomerism |
| Grant Support | |
ID/Acronym/Agency:
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1S10RR022442/RR/NCRR NIH HHS; 1S10RR023444/RR/NCRR NIH HHS; R01 GM087605/GM/NIGMS NIH HHS; R01GM087605/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Acetates; 0/Amino Acids; 0/Esters; 5TWQ1V240M/Palladium; 625-75-2/nitroacetic acid |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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