Document Detail

2-(Aminomethyl)phenols, a new class of saluretic agents. 1. Effects of nuclear substitution.
MedLine Citation:
PMID:  7452697     Owner:  NLM     Status:  MEDLINE    
A series of 2-(aminomethyl)phenols was synthesized and tested in rats and dogs for saluretic and diuretic activity. A number of these compounds exhibit a high order of activity on iv or po administration. The most active compounds belong to a subseries of 4-alkyl-6-halo derivatives of which 2, 2-(aminomethyl)-4-(1,1-dimethylethyl)-6-iodophenol, is the most active. Compound 2 also possesses significant antihypertensive activity, an adjunctive pharmacological parameter which distinguishes 2 from the other compounds prepared in this series. In addition, 2 displays both topical saluretic and antiinflammatory activities.
G E Stokker; A A Deana; S J deSolms; E M Schultz; R L Smith; E J Cragoe; J E Baer; C T Ludden; H F Russo; A Scriabine; C S Sweet; L S Watson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of medicinal chemistry     Volume:  23     ISSN:  0022-2623     ISO Abbreviation:  J. Med. Chem.     Publication Date:  1980 Dec 
Date Detail:
Created Date:  1981-03-24     Completed Date:  1981-03-24     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9716531     Medline TA:  J Med Chem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1414-27     Citation Subset:  IM    
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MeSH Terms
Administration, Oral
Chemical Phenomena
Diuretics / administration & dosage,  chemical synthesis*
Injections, Intravenous
Natriuresis / drug effects*
Phenols / administration & dosage,  chemical synthesis*,  pharmacology
Structure-Activity Relationship
Reg. No./Substance:
0/Diuretics; 0/Phenols

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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