| β(2) -Adrenergic Receptor Thr164Ile Polymorphism, Blood Pressure and Ischaemic Heart Disease in 66,750 Individuals. | |
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MedLine Citation:
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PMID: 21883537 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objectives: The β(2) -adrenergic receptor (ADRB2) is located on smooth muscle cells and is an important regulator of smooth muscle tone. The Thr164Ile polymorphism (rs1800888) in the ADRB2 gene is rare, but has profound functional consequences on receptor function and could cause lifelong elevated smooth muscle tone. We tested the hypothesis that Thr164Ile is associated with increased blood pressure, increased frequency of hypertension and increased risk of cardiovascular disease. Subjects: A total of 66,750 individuals from two large Danish general population studies were genotyped and 1,943 Thr164Ile heterozygotes and 16 homozygotes were identified. Results: Thr164Ile genotype was associated with increased systolic and diastolic blood pressure in women (trend: P=0.04 and 0.02): systolic and diastolic blood pressure increased by 5% and 2%, respectively, in female homozygotes compared with female noncarriers. All female Thr164Ile homozygotes had hypertension compared with 58% of female heterozygotes and 54% of female noncarriers (χ(2) : P=0.001). Female Thr164Ile homozygotes and heterozygotes had odds ratios for ischaemic heart disease of 2.93 (0.56-15.5) and 1.28 (1.03-1.61), respectively, compared with female noncarriers (trend: P=0.007). These differences were not observed in men. Furthermore, Gly16Arg (rs1042713) and Gln27Glu (rs1042714) in the ADRB2 gene was not associated with blood pressure, hypertension or cardiovascular disease either in the population overall or in women and men separately. Conclusions: ADRB2 Thr164Ile is associated with increased blood pressure, increased frequency of hypertension and increased risk of ischaemic heart disease among women in the general population. These findings, particularly for homozygotes, are novel. |
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Authors:
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Mette Thomsen; Morten Dahl; Anne Tybjaerg-Hansen; Børge G Nordestgaard |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-28 |
Journal Detail:
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Title: Journal of internal medicine Volume: - ISSN: 1365-2796 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-9-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8904841 Medline TA: J Intern Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 The Association for the Publication of the Journal of Internal Medicine. |
Affiliation:
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Department of Clinical Biochemistry The Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital The Copenhagen City Heart Study, Bispebjerg Hospital, Copenhagen University Hospital Faculty of Health Sciences, University of Copenhagen, Denmark. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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