Document Detail

A (2'-5')An-dependent endonuclease: tissue distribution in BALB/c mice and the effects of IFN-beta treatment and anti-IFN-alpha/beta immunoglobulin on the levels of the enzyme.
MedLine Citation:
PMID:  3171245     Owner:  NLM     Status:  MEDLINE    
A (2'-5')oligoadenylate-dependent endoribonuclease (RNase L) is an important mediator of the IFN-induced antiviral state. RNase L has been found in several different murine tissues at levels comparable to those previously observed in cultured cells. A basal level of RNase L is present in all tissues assayed. The levels of RNase L in tissues are not significantly increased in mice following treatment with interferon-beta (IFN-beta). The amount of RNase L is, however, decreased in spleen when mice are injected with rabbit antimouse IFN-alpha/beta immunoglobulin. These data suggest that relatively high levels of RNase L may be maintained in tissues by endogenous IFN-alpha/beta production.
G Floyd-Smith; J S Denton
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of interferon research     Volume:  8     ISSN:  0197-8357     ISO Abbreviation:  J. Interferon Res.     Publication Date:  1988 Aug 
Date Detail:
Created Date:  1988-11-23     Completed Date:  1988-11-23     Revised Date:  2011-06-17    
Medline Journal Info:
Nlm Unique ID:  8100396     Medline TA:  J Interferon Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  517-25     Citation Subset:  IM    
Department of Zoology, Arizona State University, Tempe 85287.
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MeSH Terms
Antibodies / immunology
Endoribonucleases / biosynthesis*
Enzyme Induction
Interferon Type I / immunology,  pharmacology*
Intestines / enzymology
Kidney / enzymology
Liver / enzymology
Lung / enzymology
Mice, Inbred BALB C
Spleen / enzymology
Reg. No./Substance:
0/Antibodies; 0/Interferon Type I; EC 3.1.-/Endoribonucleases; EC 3.1.26.-/2-5A-dependent ribonuclease

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