Document Detail

2', 5' oligo (A) synthetase levels in interferon-sensitive or resistant breast cancer cells.
MedLine Citation:
PMID:  3405096     Owner:  NLM     Status:  MEDLINE    
The levels of 2', 5' oligo (A) synthetase increase 15-fold when T47D cells are treated with human interferon or with interferon inducers. The results also show that interferon-treated T47D cells contain high levels of 2', 5' oligo (A) synthetase which upon incubation with ATP produces adenine oligonucleotides which are predominantly trimers. In contrast, MCF-7 and BT20 cells whether treated with interferon or not exhibit low 2', 5' oligo (A) synthetase activity.
A Kortsaris
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Microbiologica     Volume:  11     ISSN:  0391-5352     ISO Abbreviation:  Microbiologica     Publication Date:  1988 Apr 
Date Detail:
Created Date:  1988-09-13     Completed Date:  1988-09-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7902903     Medline TA:  Microbiologica     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  111-7     Citation Subset:  IM    
Theagenion Memorial Cancer Institute, Greece.
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MeSH Terms
2',5'-Oligoadenylate Synthetase / biosynthesis*
Breast Neoplasms / enzymology*
Enzyme Induction
Interferon Type I / pharmacology*
Poly A / pharmacology
Poly C / pharmacology
Poly U / pharmacology
Tumor Cells, Cultured
Reg. No./Substance:
0/Interferon Type I; 24937-83-5/Poly A; 27416-86-0/Poly U; 30811-80-4/Poly C; EC 2.7.7.-/2',5'-Oligoadenylate Synthetase

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