| 2-(4'-CHLOROPHENYL)-1,4-BENZOQUINONE INCREASES THE FREQUENCY OF MICRONUCLEI AND SHORTENS TELOMERES. | |
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MedLine Citation:
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PMID: 18438462 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The toxicity of polychlorinated biphenyls (PCBs) has been attributed widely to receptor-mediated effects, buttressed by the popularity of the Toxic Equivalency Factor. We propose that a crucial toxic mechanism of lower-chlorinated PCBs is their enzymatic biotransformation to electrophiles, including quinoid metabolites, that bind intracellular sulfhydryl groups, such as those found in microtubulin and enzymes like telomerase. To test this hypothesis, we have examined micronuclei induction, cell cycle, and telomere shortening in cells in culture. Our findings show a large increase in micronuclei frequency and cell cycle perturbation in V79 cells, and a marked decrease in telomere length in HaCaT cells exposed to 2-(4'-chlorophenyl)-1,4-benzoquinone (PCB3pQ). |
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Authors:
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J A Jacobus; S Flor; A Klingelhutz; L W Robertson; G Ludewig |
Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Environmental toxicology and pharmacology Volume: 25 ISSN: - ISO Abbreviation: Environ. Toxicol. Pharmacol. Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2009-3-5 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9612020 Medline TA: Environ Toxicol Pharmacol Country: - |
Other Details:
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Languages: ENG Pagination: 267-272 Citation Subset: - |
Affiliation:
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Department of Occupational and Environmental Health, University of Iowa, 100 Oakdale Campus # 124 IREH, Iowa City, IA 52242-5000. |
Export Citation:
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Descriptor/Qualifier:
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| Grant Support | |
ID/Acronym/Agency:
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P42 ES013661-01A10001//NIEHS NIH HHS; P42 ES013661-01A19003//NIEHS NIH HHS; P42 ES013661-020001//NIEHS NIH HHS; P42 ES013661-029003//NIEHS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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