Document Detail


2-(1,1'-Biphenyl-4-yl)- 1,2,4-triazole[5,1-a] isoquinoline (L 14105), a potential orally active contragestational agent for the bitch: studies in the rat, hamster and dog.
MedLine Citation:
PMID:  3761415     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the search for second generation post-coital pregnancy terminating agents belonging to the class of 2-phenyl-triazole[5,1-a]isoquinolines, the contragestational profile of (1,1'-biphenyl)-4-yl-1,2,4-triazole[5,1-a]isoquinoline, referred to as L 14105, was investigated in hamsters, rats, and bitches. Following subcutaneous or intramuscular administration in oily vehicles, L 14105 shows a very high anti-fertility activity in the three animal species, being from 1.8 to 2.5 times more effective than the parent drug, DL 717-IT. Unlike DL 717-IT, L 14105 possesses a high activity when administered by the oral route. The results obtained in the bitch make it confirm its potential use as a new orally active agent for the interruption of unwanted pregnancies.
Authors:
G Galliani; U Guzzi; G Tarzia; A Assandri
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of veterinary pharmacology and therapeutics     Volume:  9     ISSN:  0140-7783     ISO Abbreviation:  J. Vet. Pharmacol. Ther.     Publication Date:  1986 Sep 
Date Detail:
Created Date:  1986-11-19     Completed Date:  1986-11-19     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  7910920     Medline TA:  J Vet Pharmacol Ther     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  246-53     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Abortifacient Agents / pharmacology*
Abortifacient Agents, Nonsteroidal / pharmacology*
Administration, Oral
Animals
Cricetinae
Dogs
Female
Isoquinolines / administration & dosage,  blood,  pharmacology*
Kinetics
Mesocricetus
Pregnancy
Pregnancy, Animal / drug effects*
Rats
Rats, Inbred Strains
Species Specificity
Triazoles / administration & dosage,  blood,  pharmacology*
Chemical
Reg. No./Substance:
0/Abortifacient Agents; 0/Abortifacient Agents, Nonsteroidal; 0/Isoquinolines; 0/Triazoles; 75318-62-6/2-(1,1'-biphenyl-4-yl)-1,2,4-triazole(5,1-a)isoquinoline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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