| 2-(1,1'-Biphenyl-4-yl)- 1,2,4-triazole[5,1-a] isoquinoline (L 14105), a potential orally active contragestational agent for the bitch: studies in the rat, hamster and dog. | |
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MedLine Citation:
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PMID: 3761415 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the search for second generation post-coital pregnancy terminating agents belonging to the class of 2-phenyl-triazole[5,1-a]isoquinolines, the contragestational profile of (1,1'-biphenyl)-4-yl-1,2,4-triazole[5,1-a]isoquinoline, referred to as L 14105, was investigated in hamsters, rats, and bitches. Following subcutaneous or intramuscular administration in oily vehicles, L 14105 shows a very high anti-fertility activity in the three animal species, being from 1.8 to 2.5 times more effective than the parent drug, DL 717-IT. Unlike DL 717-IT, L 14105 possesses a high activity when administered by the oral route. The results obtained in the bitch make it confirm its potential use as a new orally active agent for the interruption of unwanted pregnancies. |
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Authors:
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G Galliani; U Guzzi; G Tarzia; A Assandri |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of veterinary pharmacology and therapeutics Volume: 9 ISSN: 0140-7783 ISO Abbreviation: J. Vet. Pharmacol. Ther. Publication Date: 1986 Sep |
Date Detail:
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Created Date: 1986-11-19 Completed Date: 1986-11-19 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7910920 Medline TA: J Vet Pharmacol Ther Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 246-53 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abortifacient Agents
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pharmacology* Abortifacient Agents, Nonsteroidal / pharmacology* Administration, Oral Animals Cricetinae Dogs Female Isoquinolines / administration & dosage, blood, pharmacology* Kinetics Mesocricetus Pregnancy Pregnancy, Animal / drug effects* Rats Rats, Inbred Strains Species Specificity Triazoles / administration & dosage, blood, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Abortifacient Agents; 0/Abortifacient Agents, Nonsteroidal; 0/Isoquinolines; 0/Triazoles; 75318-62-6/2-(1,1'-biphenyl-4-yl)-1,2,4-triazole(5,1-a)isoquinoline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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