| 2-(1-Hydroxethyl)-4,8-dihydrobenzo[1,2-b:5,4-b']dithiophene-4,8-dione (BTP-11) enhances the ATRA-induced differentiation in human leukemia HL-60 cells. | |
| | |
MedLine Citation:
|
PMID: 19304325 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
2-(1-Hydroxethyl)-4,8-dihydrobenzo[1,2-b:5,4-b']dithiophene-4,8-dione (BTP-11) is a potent enhancer for all-trans retinoic acid (ATRA)-induced differentiation in HL-60 cells. Combination of BTP-11 and ATRA cut down the concentration of ATRA significantly, and that BTP-11 promoted the progression of ATRA-induced into the terminal granulocytic differentiation. Further, Western blot analysis revealed that combination of BTP-11 and ATRA decreased cyclin D/CDK4 and increased C/EBPvarepsilon protein expression to arrest the cells into G0/G1 phase leading to granulocytic maturation. These results confirmed that BTP-11 is a potent enhancer for ATRA-induced differentiation of HL-60 cells, and the great developmental potential of BTP-11 will be expected. |
| | |
Authors:
|
Chun-Jen Chen; Yen-Fang Wen; Pi-Tsan Huang; Mei-Hua Hsu; Kuo-Hsiung Lee; Mei-Hwai Chen; Wuu-Chian Shin; Li-Jiau Huang; Sheng-Chu Kuo |
Related Documents
:
|
1809375 - Up-regulation of jun/ap-1 during differentiation of n1e-115 neuroblastoma cells. 6641805 - Role of glycoproteins in neuronal differentiation. inhibition of neurite outgrowth and ... 7079765 - Proton nuclear magnetic resonance of intact friend leukemia cells: phosphorylcholine in... 19301425 - N-cadherin mediates interaction between precursor cells in the subventricular zone and ... 22336595 - Cytotoxic and apoptotic effects of ethyl acetate extract of elephantopus mollis kunth. ... 22189555 - Pancreatic β-cells depend on basal expression of active atf6α-p50 for cell survival e... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-03-21 |
Journal Detail:
|
Title: Leukemia research Volume: 33 ISSN: 1873-5835 ISO Abbreviation: Leuk. Res. Publication Date: 2009 Dec |
Date Detail:
|
Created Date: 2009-09-23 Completed Date: 2009-11-23 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7706787 Medline TA: Leuk Res Country: England |
Other Details:
|
Languages: eng Pagination: 1664-9 Citation Subset: IM |
Affiliation:
|
Graduate Institute of Pharmaceutical Chemistry, China Medical University, Taichung, Taiwan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Antigens, CD
/
immunology Blotting, Western Cell Differentiation / drug effects* Drug Synergism Flow Cytometry G0 Phase G1 Phase HL-60 Cells Humans Thiophenes / pharmacology* Tretinoin / pharmacology* |
| Chemical | |
Reg. No./Substance:
|
0/2-(1-hydroxethyl)-4,8-dihydrobenzo(1,2-b:5,4-b')dithiophene-4,8-dione; 0/Antigens, CD; 0/Thiophenes; 302-79-4/Tretinoin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: GATA-2 L359 V mutation is exclusively associated with CML progression but not other hematological ma...
Next Document: A measure of community members' perceptions of the impacts of research partnerships in health and so...