Document Detail

1alpha-hydroxycholecalciferol: a promising therapeutic approach for renal osteodystrophy.
MedLine Citation:
PMID:  681163     Owner:  NLM     Status:  MEDLINE    
The effectiveness of 1alpha-hydroxycholecalciferol [1alpha-OH)D3] in healing uremic bone disease was investigated in 10 uremic patients on maintenance dialysis. Seven patients received 1alpha-(OH)D3, 2 microgram/day, for six months, and three patients served as a control group. Bone density was determined from X-rays of the second phalanx of the second digit. The apparent intestinal calcium absorption improved on treatment with 1alpha-(OH)D3, serum calcium levels and bone density significantly increased, and a significant decrease in serum alkaline phosphatase activity was observed. In one patient, reversal of uremic myopathy occurred after 17 days of 1alpha-(OH)D3 therapy.
L Gotloib; M Mines; Y Mazur; D Sklan; A L Garmizo; J Jancu; M Israeli; M Malul
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Israel journal of medical sciences     Volume:  14     ISSN:  0021-2180     ISO Abbreviation:  Isr. J. Med. Sci.     Publication Date:  1978 Jul 
Date Detail:
Created Date:  1978-10-27     Completed Date:  1978-10-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0013105     Medline TA:  Isr J Med Sci     Country:  ISRAEL    
Other Details:
Languages:  eng     Pagination:  731-5     Citation Subset:  IM    
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MeSH Terms
Absorptiometry, Photon
Alkaline Phosphatase / blood
Hydroxycholecalciferols / therapeutic use*
Hypocalcemia / blood,  drug therapy
Intestines / metabolism
Renal Osteodystrophy / blood,  drug therapy*
Uremia / drug therapy
Reg. No./Substance:
0/Hydroxycholecalciferols; EC Phosphatase

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