| (1)H NMR based metabonomics of human amniotic fluid for the metabolic characterization of fetus malformations. | |
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MedLine Citation:
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PMID: 19453159 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An NMR-metabonomic study of malformed fetuses was carried out through human amniotic fluid (HAF) analysis. Over 70 compounds were detected in control HAF by NMR. Possible confounding variables (fetus gender and gestational and maternal ages) were shown not to induce detectable compositional trends in the control group considered. Malformed fetuses showed variations in glucose, some amino acids and organic acids and proteins. In tandem with enzymatic assays, these NMR results suggest that changes in gycolysis and gluconeogenesis as well as kidney underdevelopment occur in the malformed fetuses studied here. |
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Authors:
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Gonçalo Graça; Iola F Duarte; António S Barros; Brian J Goodfellow; Sílvia Diaz; Isabel M Carreira; Ana Bela Couceiro; Eulália Galhano; Ana M Gil |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of proteome research Volume: 8 ISSN: 1535-3893 ISO Abbreviation: J. Proteome Res. Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-08-07 Completed Date: 2009-10-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101128775 Medline TA: J Proteome Res Country: United States |
Other Details:
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Languages: eng Pagination: 4144-50 Citation Subset: IM |
Affiliation:
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CICECO, Department of Chemistry, University of Aveiro, Portugal. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Amino Acids / metabolism Ammonia / metabolism Amniotic Fluid / metabolism* Female Fetus / abnormalities*, metabolism Glucose / metabolism Humans Metabolome Metabolomics / methods* Nuclear Magnetic Resonance, Biomolecular / methods* Pregnancy Principal Component Analysis |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 50-99-7/Glucose; 7664-41-7/Ammonia |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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