Document Detail

(1)H NMR based metabonomics of human amniotic fluid for the metabolic characterization of fetus malformations.
MedLine Citation:
PMID:  19453159     Owner:  NLM     Status:  MEDLINE    
An NMR-metabonomic study of malformed fetuses was carried out through human amniotic fluid (HAF) analysis. Over 70 compounds were detected in control HAF by NMR. Possible confounding variables (fetus gender and gestational and maternal ages) were shown not to induce detectable compositional trends in the control group considered. Malformed fetuses showed variations in glucose, some amino acids and organic acids and proteins. In tandem with enzymatic assays, these NMR results suggest that changes in gycolysis and gluconeogenesis as well as kidney underdevelopment occur in the malformed fetuses studied here.
Gonçalo Graça; Iola F Duarte; António S Barros; Brian J Goodfellow; Sílvia Diaz; Isabel M Carreira; Ana Bela Couceiro; Eulália Galhano; Ana M Gil
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of proteome research     Volume:  8     ISSN:  1535-3893     ISO Abbreviation:  J. Proteome Res.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-08-07     Completed Date:  2009-10-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101128775     Medline TA:  J Proteome Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4144-50     Citation Subset:  IM    
CICECO, Department of Chemistry, University of Aveiro, Portugal.
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MeSH Terms
Amino Acids / metabolism
Ammonia / metabolism
Amniotic Fluid / metabolism*
Fetus / abnormalities*,  metabolism
Glucose / metabolism
Metabolomics / methods*
Nuclear Magnetic Resonance, Biomolecular / methods*
Principal Component Analysis
Reg. No./Substance:
0/Amino Acids; 50-99-7/Glucose; 7664-41-7/Ammonia

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