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1H NMR-based metabolomic analysis of urine from preterm and term neonates.
MedLine Citation:
PMID:  21622109     Owner:  NLM     Status:  In-Data-Review    
Metabolomics is a technique used to non-invasively determine metabolic status of an organism. Aim of our study was to analyze urinary metabolic profiles in term and preterm infants in order to identify gestational age-related metabolic differences and to predict metabolic maturity at birth. Twenty-six healthy term infants and 41 preterm infants were prospectively enrolled. A urine sample was collected non-invasively within the first hours of life. Samples were analyzed by proton nuclear magnetic resonance (1H NMR) spectroscopy and NMR urine spectra were analyzed by multivariate statistical analysis. Distinct metabolic patterns were found between term infants and preterm infants, as well as between preterm infants of 23-32 weeks' gestation and those of 33-36 weeks' gestation. Individual metabolites discriminating between these groups were hippurate, tryptophan, phenylalanine, malate, tyrosine, hydroxybutyrate, N-acetyl-glutamate, and proline. Metabolomic analysis revealed distinct urinary metabolic profiles in neonates of different gestational ages, and identified the discriminating metabolites. This holistic approach appears to be a promising tool for investigating newborn metabolic maturation over time, and might lead to a tailored management of neonatal disorders.
Luigi Atzori; Roberto Antonucci; Luigi Barberini; Emanuela Locci; Flaminia Cesare Marincola; Paola Scano; Patrizia Cortesi; Rino Agostiniani; Riccardo Defraia; Aalim Weljie; Diego Gazzolo; Adolfo Lai; Vassilios Fanos
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Publication Detail:
Type:  Journal Article     Date:  2011-06-01
Journal Detail:
Title:  Frontiers in bioscience (Elite edition)     Volume:  3     ISSN:  1945-0508     ISO Abbreviation:  Front Biosci (Elite Ed)     Publication Date:  2011  
Date Detail:
Created Date:  2011-05-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101485240     Medline TA:  Front Biosci (Elite Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1005-12     Citation Subset:  IM    
Department of Toxicology, University of Cagliari, Italy.
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