| (1)H-MR spectroscopy is sensitive to subtle effects of perinatal asphyxia. | |
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MedLine Citation:
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PMID: 11571348 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The authors performed neuropsychological and (1)H-MRS studies in 18 subclinical patients with antecedents of perinatal asphyxia (PA) and in 18 matched control subjects. Patients with PA showed reduced values of N-acetylaspartate (NAA) in both the basal ganglia and the midtemporal region (MTR) and reduced NAA/choline values in the MTR. Neuropsychological testing showed group differences in tasks related to attention and memory. These results indicate persistent dysfunctions in cerebral structures vulnerable to hypoxia and demonstrate the utility of MRS for the long-term evaluation of cerebral sequelae of neonatal asphyxia. |
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Authors:
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C Mañeru; C Junqué; N Bargalló; M Olondo; F Botet; M Tallada; J Guardia; J M Mercader |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neurology Volume: 57 ISSN: 0028-3878 ISO Abbreviation: Neurology Publication Date: 2001 Sep |
Date Detail:
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Created Date: 2001-09-25 Completed Date: 2001-10-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0401060 Medline TA: Neurology Country: United States |
Other Details:
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Languages: eng Pagination: 1115-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Aspartic Acid / analogs & derivatives, metabolism* Asphyxia Neonatorum / diagnosis*, physiopathology Basal Ganglia / physiopathology Brain Damage, Chronic / diagnosis*, physiopathology Brain Mapping Child Child, Preschool Choline / metabolism* Dominance, Cerebral / physiology Female Follow-Up Studies Humans Infant Infant, Newborn Magnetic Resonance Spectroscopy* Male Temporal Lobe / physiopathology |
| Chemical | |
Reg. No./Substance:
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56-84-8/Aspartic Acid; 62-49-7/Choline; 997-55-7/N-acetylaspartate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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