| 1H MR spectroscopy of invasive ductal carcinoma: correlations with FDG PET and histologic prognostic factors. | |
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MedLine Citation:
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PMID: 20410429 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The purpose of this article is to assess the histologic prognostic relevance of choline levels obtained using (1)H MR spectroscopy with a 1.5-T MR unit in patients with invasive breast cancer and to compare the observed choline levels with the standardized uptake value obtained using FDG PET. MATERIALS AND METHODS: Single-voxel (1)H MR spectroscopy and PET/CT were performed for 50 patients with invasive ductal carcinoma (1.5-3 cm in size). The normalized choline signal was calculated using an external standard method. RESULTS: Proton MR spectroscopy detected the presence of choline in 44 cases. The average normalized choline signal was 1.1 (range, 0-3.9). The average standardized uptake value was 6.5 (range, 1.1-23). The correlation (r) between the normalized choline signal and the standardized uptake value was 0.52 (p < 0.0001). The normalized choline signal was significantly correlated with nuclear grade (p = 0.0002), triple-negative breast cancer status (p = 0.0009), and estrogen receptor negativity (p = 0.007). The standardized uptake value was significantly correlated with nuclear grade (p = 0.0002), estrogen receptor negativity (p = 0.002), and triple-negative breast cancer status (p = 0.009). No significant differences were found between the progesterone receptor-positive and negative groups or between the human epidermal growth factor receptor 2-positive and negative groups. CONCLUSION: The choline levels obtained using (1)H MR spectroscopy with a 1.5-T unit were well correlated with the standardized uptake value obtained using PET/CT and with the histologic prognostic parameters (nuclear grade, estrogen receptor status, and triple-negative lesion status). |
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Authors:
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Mitsuhiro Tozaki; Kazuei Hoshi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: AJR. American journal of roentgenology Volume: 194 ISSN: 1546-3141 ISO Abbreviation: AJR Am J Roentgenol Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-22 Completed Date: 2010-05-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7708173 Medline TA: AJR Am J Roentgenol Country: United States |
Other Details:
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Languages: eng Pagination: 1384-90 Citation Subset: AIM; IM |
Affiliation:
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Division of Diagnostic Imaging, Breast Center, Kameda Medical Center, 929 Higashi-cho, Kamogawa, Chiba 296-8602, Japan. e-tozaki@keh.biglobe.ne.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Breast Neoplasms / diagnosis*, epidemiology*, metabolism Carcinoma, Ductal, Breast / diagnosis*, epidemiology*, metabolism Female Fluorodeoxyglucose F18 / diagnostic use* Humans Japan / epidemiology Magnetic Resonance Spectroscopy / methods* Middle Aged Positron-Emission Tomography / utilization Prevalence Prognosis Protons / diagnostic use Radiopharmaceuticals / diagnostic use Reproducibility of Results Sensitivity and Specificity Statistics as Topic Tumor Markers, Biological / analysis* |
| Chemical | |
Reg. No./Substance:
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0/Protons; 0/Radiopharmaceuticals; 0/Tumor Markers, Biological; 63503-12-8/Fluorodeoxyglucose F18 |
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