Document Detail

1H-MR spectroscopy changes in transient ischemic attack patients and their correlation with perfusion-weighted imaging.
MedLine Citation:
PMID:  20707634     Owner:  NLM     Status:  MEDLINE    
PURPOSE: We investigated whether patients with transient ischemic attack (TIA) have metabolic changes in the brain.
METHODS: 35 patients with clinically diagnosed TIA were prospectively included in our study. Clinical and neurological data were compiled. 1H-MR spectroscopy and perfusion-weighted imaging were performed in all patients within 3 days of the onset of symptoms.
RESULTS: In TIA patients, the N-acetylaspartate (NAA)/choline (Cho) ratio in noninfarcted regions was significantly decreased in the symptomatic hemisphere (1.33 +/- 0.38) compared with the asymptomatic hemisphere (1.51 +/- 0.41, p < .05). Patients with a history of prior TIA had a significantly decreased NAA/Cho ratio in both the symptomatic (p < .05) and asymptomatic (p < .05) hemispheres compared with TIA patients without a prior TIA. TIA patients with diffusion-weighted imaging lesions had a significantly increased lactate/NAA ratio in both the symptomatic (p < .05) and asymptomatic (p < .05) hemispheres compared with TIA patients without lesions. The relative cerebral blood flow (rCBF) value was directly related to the symptomatic Cho/creatine (Cr) value (r = 0.81, p < .01). The higher the rCBF value, the higher the symptomatic Cho/Cr value.
CONCLUSIONS: TIA patients have neurological deficits that are transient; however, metabolic damage to the brain is present up to 3 days after the onset of the symptoms. These metabolic changes are not restricted to the symptomatic hemisphere or to areas close to ischemic lesions and the changes are related in the CBF.
Tong Tong; Yao Zhenwei; Feng Xiaoyuan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The International journal of neuroscience     Volume:  120     ISSN:  1563-5279     ISO Abbreviation:  Int. J. Neurosci.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-16     Completed Date:  2010-12-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0270707     Medline TA:  Int J Neurosci     Country:  England    
Other Details:
Languages:  eng     Pagination:  596-601     Citation Subset:  IM    
Department of Radiology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
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MeSH Terms
Aspartic Acid / analogs & derivatives,  metabolism
Brain / blood supply,  metabolism*,  physiopathology*
Cerebrovascular Circulation
Choline / metabolism
Creatine / metabolism
Ischemic Attack, Transient / metabolism*,  physiopathology*
Lactic Acid / metabolism
Magnetic Resonance Angiography / methods*
Magnetic Resonance Spectroscopy / methods*
Middle Aged
Time Factors
Reg. No./Substance:
1333-74-0/Hydrogen; 50-21-5/Lactic Acid; 56-84-8/Aspartic Acid; 57-00-1/Creatine; 62-49-7/Choline; 997-55-7/N-acetylaspartate

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