| 1H-MR spectroscopy changes in transient ischemic attack patients and their correlation with perfusion-weighted imaging. | |
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MedLine Citation:
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PMID: 20707634 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: We investigated whether patients with transient ischemic attack (TIA) have metabolic changes in the brain. METHODS: 35 patients with clinically diagnosed TIA were prospectively included in our study. Clinical and neurological data were compiled. 1H-MR spectroscopy and perfusion-weighted imaging were performed in all patients within 3 days of the onset of symptoms. RESULTS: In TIA patients, the N-acetylaspartate (NAA)/choline (Cho) ratio in noninfarcted regions was significantly decreased in the symptomatic hemisphere (1.33 +/- 0.38) compared with the asymptomatic hemisphere (1.51 +/- 0.41, p < .05). Patients with a history of prior TIA had a significantly decreased NAA/Cho ratio in both the symptomatic (p < .05) and asymptomatic (p < .05) hemispheres compared with TIA patients without a prior TIA. TIA patients with diffusion-weighted imaging lesions had a significantly increased lactate/NAA ratio in both the symptomatic (p < .05) and asymptomatic (p < .05) hemispheres compared with TIA patients without lesions. The relative cerebral blood flow (rCBF) value was directly related to the symptomatic Cho/creatine (Cr) value (r = 0.81, p < .01). The higher the rCBF value, the higher the symptomatic Cho/Cr value. CONCLUSIONS: TIA patients have neurological deficits that are transient; however, metabolic damage to the brain is present up to 3 days after the onset of the symptoms. These metabolic changes are not restricted to the symptomatic hemisphere or to areas close to ischemic lesions and the changes are related in the CBF. |
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Authors:
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Tong Tong; Yao Zhenwei; Feng Xiaoyuan |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The International journal of neuroscience Volume: 120 ISSN: 1563-5279 ISO Abbreviation: Int. J. Neurosci. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-16 Completed Date: 2010-12-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0270707 Medline TA: Int J Neurosci Country: England |
Other Details:
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Languages: eng Pagination: 596-601 Citation Subset: IM |
Affiliation:
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Department of Radiology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. t983352@126.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aspartic Acid / analogs & derivatives, metabolism Brain / blood supply, metabolism*, physiopathology* Cerebrovascular Circulation Choline / metabolism Creatine / metabolism Female Humans Hydrogen Ischemic Attack, Transient / metabolism*, physiopathology* Lactic Acid / metabolism Magnetic Resonance Angiography / methods* Magnetic Resonance Spectroscopy / methods* Male Middle Aged Time Factors |
| Chemical | |
Reg. No./Substance:
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1333-74-0/Hydrogen; 50-21-5/Lactic Acid; 56-84-8/Aspartic Acid; 57-00-1/Creatine; 62-49-7/Choline; 997-55-7/N-acetylaspartate |
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