| (19)F MRI oximetry: simulation of perfluorocarbon distribution impact. | |
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MedLine Citation:
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PMID: 21444970 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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In (19)F MRI oximetry, a method used to image tumour hypoxia, perfluorocarbons serve as oxygenation markers. The goal of this study is to evaluate the impact of perfluorocarbon distribution and concentration in (19)F MRI oximetry through a computer simulation. The simulation studies the correspondence between (19)F measured (pO(FNMR)(2)) and actual tissue oxygen tension (pO(2)) for several tissue perfluorocarbon distributions. For this, a Krogh tissue model is implemented which incorporates the presence of perfluorocarbons in blood and tissue. That is, in tissue the perfluorocarbons are distributed homogeneously according to Gaussian diffusion profiles, or the perfluorocarbons are concentrated in the capillary wall. Using these distributions, the oxygen tension in the simulation volume is calculated. The simulated mean oxygen tension is then compared with pO(FNMR)(2), the (19)F MRI-based measure of pO(2) and with pO(0)(2), pO(2) in the absence of perfluorocarbons. The agreement between pO(FNMR)(2) and actual pO(2) is influenced by vascular density and perfluorocarbon distribution. The presence of perfluorocarbons generally gives rise to a pO(2) increase in tissue. This effect is enhanced when perfluorocarbons are also present in blood. Only the homogeneous perfluorocarbon distribution in tissue with no perfluorocarbons in blood guarantees small deviations of pO(FNMR)(2) from pO(2). Hence, perfluorocarbon distribution in tissue and blood has a serious impact on the reliability of (19)F MRI-based measures of oxygen tension. In addition, the presence of perfluorocarbons influences the actual oxygen tension. This finding may be of great importance for further development of (19)F MRI oximetry. |
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Authors:
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S H Baete; J Vandecasteele; Y De Deene |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-28 |
Journal Detail:
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Title: Physics in medicine and biology Volume: 56 ISSN: 1361-6560 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401220 Medline TA: Phys Med Biol Country: - |
Other Details:
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Languages: ENG Pagination: 2535-2557 Citation Subset: - |
Affiliation:
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Department of Radiation Oncology and Experimental Cancer Research, Ghent University, De Pintelaan 185, 9000 Gent, Belgium. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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