| 1999 Curt P. Richter award. Glucocorticoids and the regulation of memory consolidation. | |
| | |
MedLine Citation:
|
PMID: 10737694 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
This paper summarizes recent findings on the amygdala's role in mediating acute effects of glucocorticoids on memory consolidation in rats. Posttraining activation of glucocorticoid-sensitive pathways involving glucocorticoid receptors (GRs or type II) enhances memory consolidation in a dose-dependent inverted-U fashion. Selective lesions of the basolateral nucleus of the amygdala (BLA) or infusions of beta-adrenoceptor antagonists into the BLA block the memory-modulatory effects of systemic injections of glucocorticoids. Additionally, posttraining infusions of a specific GR agonist administered directly into the BLA enhance memory consolidation, whereas those of a GR antagonist impair. These findings indicate that glucocorticoid effects on memory consolidation are mediated, in part, by an activation of GRs in the BLA and that the effects require beta-adrenergic activity in the BLA. Other findings indicate that the BLA interacts with the hippocampus in mediating glucocorticoid-induced modulatory influences on memory consolidation. Lesions of the BLA or inactivation of beta-adrenoceptors within the BLA also block the memory-modulatory effects of intrahippocampal administration of a GR agonist or antagonist. These findings are in agreement with the general hypothesis that the BLA integrates hormonal and neuromodulatory influences on memory consolidation. However, the BLA is not a permanent locus of storage for this information, but modulates consolidation processes for explicit/associative memories in other brain regions, including the hippocampus. |
| | |
Authors:
|
B Roozendaal |
Related Documents
:
|
22404164 - Acquisition and generalization of fear conditioning are not modulated by the bdnf-val66... 21912594 - Discriminating grotesque from typical faces: evidence from the thatcher illusion. 15174934 - Evidence of a time-dependent long-term stage of memory for a spatial learning task in t... 22984804 - Performance of healthy participants on the iowa gambling task. 21479254 - Expertise reduces neural cost but does not modulate repetition suppression. 9132714 - Locus of control, latent inhibition and reaction times in a semantic (left-hemisphere) ... |
Publication Detail:
|
Type: Historical Article; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
|
Title: Psychoneuroendocrinology Volume: 25 ISSN: 0306-4530 ISO Abbreviation: Psychoneuroendocrinology Publication Date: 2000 Apr |
Date Detail:
|
Created Date: 2000-05-17 Completed Date: 2000-05-17 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 7612148 Medline TA: Psychoneuroendocrinology Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 213-38 Citation Subset: IM; Q |
Affiliation:
|
Center for the Neurobiology of Learning and Memory and Department of Neurobiology and Behavior, University of California, Irvine 92697-3800, USA. broozend@uci.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Amygdala
/
drug effects,
metabolism* Animals Awards and Prizes Dose-Response Relationship, Drug Glucocorticoids / history, metabolism, pharmacology* Hippocampus / drug effects, physiology History, 20th Century Memory / drug effects*, physiology Neural Pathways / drug effects, physiology Neurobiology / history Norepinephrine / metabolism Rats Reaction Time / drug effects, physiology Receptors, Glucocorticoid / metabolism Stress, Physiological / metabolism Synaptic Transmission / drug effects, physiology |
| Grant Support | |
ID/Acronym/Agency:
|
MH12526/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Glucocorticoids; 0/Receptors, Glucocorticoid; 51-41-2/Norepinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The joint effect of apolipoprotein E epsilon4 and MRI findings on lower-extremity function and decli...
Next Document: Relationship between depressive symptoms and diabetes among native Hawaiians.