Document Detail

1999 Curt P. Richter award. Glucocorticoids and the regulation of memory consolidation.
MedLine Citation:
PMID:  10737694     Owner:  NLM     Status:  MEDLINE    
This paper summarizes recent findings on the amygdala's role in mediating acute effects of glucocorticoids on memory consolidation in rats. Posttraining activation of glucocorticoid-sensitive pathways involving glucocorticoid receptors (GRs or type II) enhances memory consolidation in a dose-dependent inverted-U fashion. Selective lesions of the basolateral nucleus of the amygdala (BLA) or infusions of beta-adrenoceptor antagonists into the BLA block the memory-modulatory effects of systemic injections of glucocorticoids. Additionally, posttraining infusions of a specific GR agonist administered directly into the BLA enhance memory consolidation, whereas those of a GR antagonist impair. These findings indicate that glucocorticoid effects on memory consolidation are mediated, in part, by an activation of GRs in the BLA and that the effects require beta-adrenergic activity in the BLA. Other findings indicate that the BLA interacts with the hippocampus in mediating glucocorticoid-induced modulatory influences on memory consolidation. Lesions of the BLA or inactivation of beta-adrenoceptors within the BLA also block the memory-modulatory effects of intrahippocampal administration of a GR agonist or antagonist. These findings are in agreement with the general hypothesis that the BLA integrates hormonal and neuromodulatory influences on memory consolidation. However, the BLA is not a permanent locus of storage for this information, but modulates consolidation processes for explicit/associative memories in other brain regions, including the hippocampus.
B Roozendaal
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Publication Detail:
Type:  Historical Article; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Psychoneuroendocrinology     Volume:  25     ISSN:  0306-4530     ISO Abbreviation:  Psychoneuroendocrinology     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-05-17     Completed Date:  2000-05-17     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7612148     Medline TA:  Psychoneuroendocrinology     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  213-38     Citation Subset:  IM; Q    
Center for the Neurobiology of Learning and Memory and Department of Neurobiology and Behavior, University of California, Irvine 92697-3800, USA.
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MeSH Terms
Amygdala / drug effects,  metabolism*
Awards and Prizes
Dose-Response Relationship, Drug
Glucocorticoids / history,  metabolism,  pharmacology*
Hippocampus / drug effects,  physiology
History, 20th Century
Memory / drug effects*,  physiology
Neural Pathways / drug effects,  physiology
Neurobiology / history
Norepinephrine / metabolism
Reaction Time / drug effects,  physiology
Receptors, Glucocorticoid / metabolism
Stress, Physiological / metabolism
Synaptic Transmission / drug effects,  physiology
Grant Support
Reg. No./Substance:
0/Glucocorticoids; 0/Receptors, Glucocorticoid; 51-41-2/Norepinephrine

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