Document Detail


The 1992 measles epidemic in Cape Town--a changing epidemiological pattern.
MedLine Citation:
PMID:  7740350     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Over the last 6 years there has been a decline in the incidence of measles in Cape Town. However, during August 1992 an outbreak occurred, with cases reported at many schools in children presumably immunised. The objectives of this study were to characterise the epidemic in Cape Town and to determine possible reasons for the outbreak. The investigation consisted of two components--a description of the epidemic and an investigation of an outbreak at one primary school. Results indicate that during the last 4 months of the year, 757 cases were notified in Cape Town, compared with 144 in the first 8 months. The epidemic affected mainly white and coloured children over 5 years of age (P < 0.001). In contrast, during the period before the epidemic most cases occurred in black children and in those aged less than 1 year (P < 0.001). There was no significant increase in hospitalised cases. Investigation of the outbreak at one school revealed that the attack rate was 7.6% (25/329 children). Immunisation coverage (at least one dose of any measles vaccine) was 91% and vaccine efficacy was estimated to be 79% (95% CI 55-90); it was highest for monovalent measles (100%) and lowest for measles-mumps-rubella (74%). The epidemiology of measles in Cape Town has thus changed as evinced in this epidemic, with an increase in the number of cases occurring in older, previously vaccinated children. The possible reasons for this include both primary and secondary vaccine failure.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
N Coetzee; G D Hussey; G Visser; P Barron; A Keen
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde     Volume:  84     ISSN:  0256-9574     ISO Abbreviation:  S. Afr. Med. J.     Publication Date:  1994 Mar 
Date Detail:
Created Date:  1995-06-08     Completed Date:  1995-06-08     Revised Date:  2014-09-12    
Medline Journal Info:
Nlm Unique ID:  0404520     Medline TA:  S Afr Med J     Country:  SOUTH AFRICA    
Other Details:
Languages:  eng     Pagination:  145-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Age Distribution
Child
Child, Preschool
Disease Notification / statistics & numerical data
Disease Outbreaks*
Humans
Infant
Male
Measles / epidemiology*,  ethnology,  immunology
South Africa / epidemiology
Vaccination / standards

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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