Document Detail

Alteration of correlation between serum pepsinogen concentrations and gastric acid secretion after H. pylori eradication.
MedLine Citation:
PMID:  19440811     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The measurement of serum pepsinogens is clinically useful to represent gastric acid secretion. Since both serum pepsinogens and gastric acid secretion are considerably altered by H. pylori eradication, the correlation between these two parameters could be different prior to and after eradication. In this study, we investigated the correlation between the two parameters prior to and after eradication. METHODS: One hundred eighteen H. pylori-positive patients with peptic ulcers or chronic gastritis were enrolled in this retrospective analysis. In all participants both the measurement of serum pepsinogens and the determination of gastric acid secretion were performed prior to and at 1 month after successful eradication. In 85 subjects, the same assessments were repeated at 7 months. Correlations between serum pepsinogens and gastric acid secretion were assessed using linear regression analysis. RESULTS: The pepsinogen I/II ratio (r = 0.56) was a better indicator of gastric acid secretion in H. pylori-infected subjects than pepsinogen I itself (r = 0.31). Eradication of H. pylori altered the association, causing pepsinogen I (r = 0.55) to become a better indicator of gastric acid secretion compared with the pepsinogen I/II ratio (r = 0.40) at 1 month after eradication, followed by similar tendencies at 7 months. CONCLUSION: Using different serum biomarkers (pepsinogen I/II ratio prior to eradication or pepsinogen I after eradication), the measurement of serum pepsinogens is useful for predicting the individual gastric acid secretion level not only in H. pylori-infected subjects, but also in subjects with histories of eradication of the infection.
Katsunori Iijima; Tomoyuki Koike; Yasuhiko Abe; Nobuyuki Ara; Kaname Uno; Akira Imatani; Shuichi Ohara; Tooru Shimosegawa
Publication Detail:
Type:  Journal Article     Date:  2009-05-14
Journal Detail:
Title:  Journal of gastroenterology     Volume:  44     ISSN:  0944-1174     ISO Abbreviation:  J. Gastroenterol.     Publication Date:  2009  
Date Detail:
Created Date:  2009-08-12     Completed Date:  2009-10-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9430794     Medline TA:  J Gastroenterol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  819-25     Citation Subset:  IM    
Division of Gastroenterology, Tohoku University Graduate School of Medicine, Aobaku, Sendai, Japan.
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MeSH Terms
Biological Markers / blood
Chronic Disease
Follow-Up Studies
Gastric Acid / secretion*
Gastritis / drug therapy,  microbiology
Helicobacter Infections / blood,  drug therapy,  metabolism*,  microbiology
Helicobacter pylori / drug effects,  isolation & purification
Linear Models
Middle Aged
Pepsinogen A / blood*
Pepsinogen C / blood*
Peptic Ulcer / drug therapy,  microbiology
Retrospective Studies
Reg. No./Substance:
0/Biological Markers; 61536-72-9/Pepsinogen C; 9001-10-9/Pepsinogen A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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