Document Detail


Breastmilk from allergic mothers can protect offspring from allergic airway inflammation.
MedLine Citation:
PMID:  19301986     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Breastfeeding is associated with a reduced risk of developing asthma in children. Using a murine model we previously demonstrated that mothers with Th1-type immunity to ovalbumin (OVA) transfer antigen-specific protection from OVA-induced allergic airway disease (AAD) to their offspring. The aim of this study was to evaluate the contribution of breastmilk and maternal B cell immunity from allergic mothers in the vertical transmission of protection from AAD.
METHODS: This was investigated using an adoptive nursing strategy. Naive offspring were nursed by allergic wild-type or B cell-deficient foster mothers with histories of Th2-type immunity to OVA. Following weaning, offspring were immunized with OVA-Al(OH)(3) and challenged with aerosolized OVA to induce AAD.
RESULTS: Offspring nursed by wild-type OVA-immune foster mothers demonstrated lower levels of OVA-specific immunoglobulin E, interleukin-5, and airway eosinophilia than progeny nursed by naive control mothers. In contrast, offspring nursed by B cell-deficient OVA-immune foster mothers had similar parameters of OVA-induced AAD as progeny nursed by naive control mothers.
CONCLUSIONS: These data demonstrate the ability of breastmilk from allergic mothers to protect offspring from AAD was dependent on intact maternal B cell immunity. Nursing alone, when done by wild-type mothers with AAD, was sufficient for offspring to acquire the antigen-specific protective factor(s) from breastmilk.
Authors:
Adam P Matson; Roger S Thrall; Ektor Rafti; Lynn Puddington
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine     Volume:  4     ISSN:  1556-8342     ISO Abbreviation:  Breastfeed Med     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-09-10     Completed Date:  2009-11-23     Revised Date:  2011-09-26    
Medline Journal Info:
Nlm Unique ID:  101260777     Medline TA:  Breastfeed Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  167-74     Citation Subset:  IM    
Affiliation:
Department of Immunology, University of Connecticut Health Center, Farmington, Connecticut 06030-1319, USA.
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MeSH Terms
Descriptor/Qualifier:
Allergens / adverse effects
Animals
Animals, Suckling
Antibodies / blood,  immunology
Asthma / immunology,  prevention & control*
B-Lymphocytes / immunology*
Disease Models, Animal
Female
Humans
Immune Tolerance
Immunity, Maternally-Acquired*
Immunization*
Immunoglobulin G / blood,  immunology
Infant, Newborn
Interleukin-5 / blood,  immunology
Mice
Mice, Inbred BALB C
Milk, Human / immunology*
Ovalbumin / adverse effects,  immunology
Pregnancy
Risk Factors
Grant Support
ID/Acronym/Agency:
HL069083/HL/NHLBI NIH HHS; HL080508/HL/NHLBI NIH HHS; R01 HL069083-03/HL/NHLBI NIH HHS; R01 HL069083-04/HL/NHLBI NIH HHS; R01 HL080508-02/HL/NHLBI NIH HHS; R01 HL080508-03/HL/NHLBI NIH HHS; R01 HL080508-04/HL/NHLBI NIH HHS; R01 HL080508-05/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Allergens; 0/Antibodies; 0/Immunoglobulin G; 0/Interleukin-5; 9006-59-1/Ovalbumin
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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