| Breastmilk from allergic mothers can protect offspring from allergic airway inflammation. | |
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MedLine Citation:
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PMID: 19301986 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Breastfeeding is associated with a reduced risk of developing asthma in children. Using a murine model we previously demonstrated that mothers with Th1-type immunity to ovalbumin (OVA) transfer antigen-specific protection from OVA-induced allergic airway disease (AAD) to their offspring. The aim of this study was to evaluate the contribution of breastmilk and maternal B cell immunity from allergic mothers in the vertical transmission of protection from AAD. METHODS: This was investigated using an adoptive nursing strategy. Naive offspring were nursed by allergic wild-type or B cell-deficient foster mothers with histories of Th2-type immunity to OVA. Following weaning, offspring were immunized with OVA-Al(OH)(3) and challenged with aerosolized OVA to induce AAD. RESULTS: Offspring nursed by wild-type OVA-immune foster mothers demonstrated lower levels of OVA-specific immunoglobulin E, interleukin-5, and airway eosinophilia than progeny nursed by naive control mothers. In contrast, offspring nursed by B cell-deficient OVA-immune foster mothers had similar parameters of OVA-induced AAD as progeny nursed by naive control mothers. CONCLUSIONS: These data demonstrate the ability of breastmilk from allergic mothers to protect offspring from AAD was dependent on intact maternal B cell immunity. Nursing alone, when done by wild-type mothers with AAD, was sufficient for offspring to acquire the antigen-specific protective factor(s) from breastmilk. |
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Authors:
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Adam P Matson; Roger S Thrall; Ektor Rafti; Lynn Puddington |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine Volume: 4 ISSN: 1556-8342 ISO Abbreviation: Breastfeed Med Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-09-10 Completed Date: 2009-11-23 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 101260777 Medline TA: Breastfeed Med Country: United States |
Other Details:
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Languages: eng Pagination: 167-74 Citation Subset: IM |
Affiliation:
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Department of Immunology, University of Connecticut Health Center, Farmington, Connecticut 06030-1319, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Allergens
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adverse effects Animals Animals, Suckling Antibodies / blood, immunology Asthma / immunology, prevention & control* B-Lymphocytes / immunology* Disease Models, Animal Female Humans Immune Tolerance Immunity, Maternally-Acquired* Immunization* Immunoglobulin G / blood, immunology Infant, Newborn Interleukin-5 / blood, immunology Mice Mice, Inbred BALB C Milk, Human / immunology* Ovalbumin / adverse effects, immunology Pregnancy Risk Factors |
| Grant Support | |
ID/Acronym/Agency:
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HL069083/HL/NHLBI NIH HHS; HL080508/HL/NHLBI NIH HHS; R01 HL069083-03/HL/NHLBI NIH HHS; R01 HL069083-04/HL/NHLBI NIH HHS; R01 HL080508-02/HL/NHLBI NIH HHS; R01 HL080508-03/HL/NHLBI NIH HHS; R01 HL080508-04/HL/NHLBI NIH HHS; R01 HL080508-05/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Allergens; 0/Antibodies; 0/Immunoglobulin G; 0/Interleukin-5; 9006-59-1/Ovalbumin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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