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[(18)F]Fluorination of an arylboronic ester using [(18)F]selectfluor bis(triflate): application to 6-[(18)F]fluoro-l-DOPA.
MedLine Citation:
PMID:  23321570     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The Ag-mediated electrophilic [(18)F]fluorination of an arylboronic ester is reported. This new radiochemical transformation uses [(18)F]selectfluor bis(triflate) in acetone. The process gave 6-[(18)F]fluoro-l-DOPA with a RCY of 19 ± 12% and a specific activity of 2.6 ± 0.3 GBq μmol(-1).
Authors:
Ida S R Stenhagen; Anna K Kirjavainen; Sarita J Forsback; Charlotte G Jørgensen; Edward G Robins; Sajinder K Luthra; Olof Solin; Véronique Gouverneur
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-16
Journal Detail:
Title:  Chemical communications (Cambridge, England)     Volume:  -     ISSN:  1364-548X     ISO Abbreviation:  Chem. Commun. (Camb.)     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9610838     Medline TA:  Chem Commun (Camb)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK. veronique.gouverneur@chem.ox.ac.uk.
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