| 18F-fluoride PET/CT for assessing bone involvement in prostate and breast cancers. | |
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MedLine Citation:
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PMID: 21076343 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the accuracy of F-fluoride PET/computed tomography (CT) to detect bone metastases (BMs) in a breast and prostate cancer population, using magnetic resonance imaging (MRI) or thin-slice CT as a gold standard. METHODS: We have prospectively included 34 patients with breast (N=24) or prostate cancer (N=10) at high risk of BMs. Whole-body PET/CT (low-dose CT) and bone scintigraphy (BS) with single photon emission CT were obtained for all 34 patients and the results compared with a radiological gold standard. RESULTS: Out of the 386 foci detected by PET/CT, 219 (56.7%) could be verified by CT or MRI. Eighty-six additional foci were detected by BS (n=46) or seen only by CT (n=9), MRI (n=23), or both CT and MRI (n=8). The total number of verified lesions was therefore 274 (58.1%), including 119 (43.4%) benign and 155 (56.6%) BM. The sensitivity, specificity, and accuracy of F-fluoride PET/CT were 76, 84.2, and 80%, respectively. For BS, they were 44.8, 79.2, and 60%, respectively. Sensitivity significantly decreased for the lytic lesions. The accuracy of PET/CT was significantly superior to BS for pelvic and lumbar lesions. PET/CT provided a correct diagnosis (M+/M0) in 32 of 33 patients (one false positive) compared with 28 of 33 with BS (four false positive, one false positive). CONCLUSION: F-fluoride PET/CT is significantly more accurate than BS for detecting BMs from breast and prostate cancers. |
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Authors:
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Nadia Withofs; Benjamin Grayet; Tino Tancredi; Andrée Rorive; Christine Mella; Fabrice Giacomelli; Frédéric Mievis; Joël Aerts; David Waltregny; Guy Jerusalem; Roland Hustinx |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Nuclear medicine communications Volume: 32 ISSN: 1473-5628 ISO Abbreviation: Nucl Med Commun Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-01-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8201017 Medline TA: Nucl Med Commun Country: England |
Other Details:
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Languages: eng Pagination: 168-76 Citation Subset: IM |
Affiliation:
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aDivision of Nuclear Medicine bDepartment of Medical Imaging cDivision of Medical Oncology dDivision of Urology, CHU Liège eCyclotron Research Center, University of Liège, Liège, Belgium. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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