| 18F-Fluorodeoxyglucose-PET/CT to evaluate tumor, nodal disease, and gross tumor volume of oropharyngeal and oral cavity cancer: comparison with MR imaging and validation with surgical specimen. | |
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MedLine Citation:
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PMID: 19727695 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: The purpose of this paper is to evaluate the impact of adding combined 18F-PET/CT to MRI for T and N staging of the oral and oropharyngeal cancer and calculation of the gross tumor volume (GTV) having histopathology as reference standard. METHODS: PET/CT and MRI were performed in 66 patients with suspected oral and oropharyngeal cancer (41 primary tumors/25 recurrent tumors) and nodal disease (114 nodes). Statistical analysis included the McNemar test, sensitivity, specificity for the diagnostic modalities as well as regression analysis, and Bland-Altman graphs for calculated tumor volumes. RESULTS: There was no statistically significant difference between the two modalities compared to pathological findings regarding detection of disease (P > or =0.72). The sensitivity/specificity for tumor detection were 100/80% and 96.72/60% for MRI and PET/CT, respectively. The sensitivity/specificity for nodal metastases were 88.46/75% and 83.81/73.91% for MRI and PET/CT, respectively. In 18% of cases, the MRI-based T staging resulted in an overestimation of the pathologic tumor stage. The corresponding rate for PET/CT was 22%. Regarding the treated necks, both modalities showed 100% sensitivity for detection of the recurrent lesions. In necks with histologically N0 staging, MRI and PET/CT gave 22% and 26% false positive findings, respectively. The mean tumor volume in the pathologic specimen was 16.6 +/- 18.6 ml, the mean volume derived by the MR imaging was 17.6 +/- 19.1 ml while the estimated by PET/CT volume was 18.8 +/- 18.1 ml (P < or =0.007 between the three methods). The Bland-Altman analysis showed a better agreement between PET/CT and MRI. CONCLUSION: The diagnostic performance of FDG-PET/CT in the local staging of oral cancer is not superior to MRI. |
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Authors:
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Oliver Seitz; Nicole Chambron-Pinho; Markus Middendorp; Rober Sader; Martin Mack; Thomas J Vogl; Sotirios Bisdas |
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Publication Detail:
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Type: Comparative Study; Journal Article; Validation Studies |
Journal Detail:
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Title: Neuroradiology Volume: 51 ISSN: 1432-1920 ISO Abbreviation: Neuroradiology Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-09-17 Completed Date: 2009-12-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1302751 Medline TA: Neuroradiology Country: Germany |
Other Details:
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Languages: eng Pagination: 677-86 Citation Subset: IM |
Affiliation:
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Department of Oromaxillofacial Surgery, JW Goethe University, Frankfurt, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Female Fluorodeoxyglucose F18 / diagnostic use Humans Lymph Nodes / pathology, radiography, radionuclide imaging Lymphatic Metastasis / diagnosis, pathology Magnetic Resonance Imaging / methods* Male Middle Aged Mouth Neoplasms / diagnosis*, pathology, therapy Neoplasm Recurrence, Local / diagnosis, pathology Neoplasm Staging Oropharyngeal Neoplasms / diagnosis*, pathology, therapy Positron-Emission Tomography / methods* Retrospective Studies Sensitivity and Specificity Tomography, X-Ray Computed / methods* |
| Chemical | |
Reg. No./Substance:
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63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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