Document Detail

18F-Fluoride PET/CT Allows Detection of Hyperostosis and Osseous Involvement in Meningioma: Initial Experience.
MedLine Citation:
PMID:  23412601     Owner:  NLM     Status:  In-Data-Review    
PURPOSE: The present study was conducted to assess the diagnostic performance of F-fluoride PET/CT in evaluating hyperostosis and osseous involvement in patients with meningioma.
PATIENTS AND METHODS: Thirty-four patients with meningioma (mean age, 61 years) underwent F-fluoride PET/CT before surgery. In 24 patients (71%), F-FDG PET/CT was also given before surgery, and the results were compared. The images were reviewed by 2 board-certified nuclear medicine specialists who were unaware of any clinical information and a consensus was reached. Uptake patterns and measurements of tracers were compared with pathological findings from resected specimens, with hyperostosis and osseous involvement as the reference standard.
RESULTS: There were 27 grade I tumors (79%) and 7 grade II tumors (21%). The primary tumor focus was identified in each patient using both F-fluoroide PET/CT and F-FDG PET/CT, but there were no significant correlations in the degree of uptake between the 2 tracers. The SUVmax, SUVmax corrected for lean body mass (SULmax), and tumor metabolic volume (TMV) for F-fluoride and F-FDG were greater in grade II tumors than in grade I tumors. Hyperostosis and osseous involvement was identified in 12 tumors (38%). The SUVmax, SULmax, and TMV of tumors visualized with F-fluoride PET/CT were greater in tumors with hyperostosis and osseous involvement than in those without (P = 0.005, P = 0.003, and P = 0.006, respectively). In contrast, the SUVmax, SULmax, and TMV of tumors visualized with F-FDG PET/CT were similar regardless of hyperostosis or osseous involvement.
CONCLUSIONS: F-fluoride PET/CT may improve detection of hyperostosis and osseous involvement in patients with meningioma.
Ukihide Tateishi; Kensuke Tateishi; Kazuya Shizukuishi; Ayako Shishikura; Hidetoshi Murata; Tomio Inoue; Nobutaka Kawahara
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical nuclear medicine     Volume:  38     ISSN:  1536-0229     ISO Abbreviation:  Clin Nucl Med     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7611109     Medline TA:  Clin Nucl Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e125-31     Citation Subset:  IM    
From the Departments of *Radiology, and †Neurosurgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
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