| 18F-FDG-PET/CT for detection of extramedullary acute myeloid leukemia. | |
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MedLine Citation:
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PMID: 21685468 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Myeloid Sarcoma in acute myeloid leukemia has been clearly defined by the World Health Organization but studies regarding the prevalence and the prognostic impact of extramedullary acute myeloid leukemia have not been conducted. We performed 18Fluoro-deoxy-Glucose Positron Emission Tomography / Computed Tomography scans in 10 patients with de novo and relapsed acute myeloid leukemia and histologically proven extramedullary disease. The scans were able to detect the known extramedullary lesions in nine out of 10 patients (90%). Furthermore, additional extramedullary sites were detected in six patients (60%). Thus, detection of known and clinically cryptic extramedullary manifestations of acute myeloid leukemia is possible. Since most of these patients relapsed within a short period of time after initiation of therapy or had refractory disease, the detection of extramedullary disease with 18Fluoro-deoxy-Glucose Positron Emission Tomography / Computed Tomography might be helpful to develop individual treatment algorithms for these high-risk patients. |
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Authors:
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Friedrich Stolzel; Christoph Rollig; Jorgen Radke; Brigitte Mohr; Uwe Platzbecker; Martin Bornhauser; Tobias Paulus; Gerhard Ehninger; Klaus Zophel; Markus Schaich |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-6-17 |
Journal Detail:
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Title: Haematologica Volume: - ISSN: 1592-8721 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-6-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0417435 Medline TA: Haematologica Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Germany; |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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