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18F-FDG Uptake Changes in Liver and Mediastinum During Chemotherapy in Patients With Diffuse Large B-cell Lymphoma.
MedLine Citation:
PMID:  22955068     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
PURPOSE: The main objective of this study was to assess the intrasubject and intersubjects variability of F-FDG uptake in liver (LIV) and mediastinum (MBP) among patients with diffuse large B-cell lymphoma (DLBCL), treated with different chemotherapy regimens.
PATIENTS AND METHODS: Fifty patients with DLBCL who underwent F-FDG PET/CT scan at baseline, after a few cycles of therapy (interim PET) and on completion of therapy (final PET), were enrolled retrospectively. SUVmean and SUVmax values for LIV and MBP, their differences (LIV - MBP SUVmean and LIV - MBP SUVmax), and their changes were calculated, respectively.
RESULTS: Liver uptake significantly increased in the interim in comparison with baseline and final PET, respectively, whereas MBP activity remained stable during chemotherapy. The intersubject variability of F-FDG uptake in LIV and MBP ranged from 20.2% to 25.4%.
CONCLUSIONS: The variability of the LIV uptake during chemotherapy should be taken into account when this parameter is used to score the interim PET scan and to make decisions in defining response-adapted therapeutic strategies. Vice versa, the stability of MBP activity during therapy provides a more reliable benchmark for the response assessment.Finally, the intersubjects variability of both parameters should be considered when the visual evaluation of the interim PET is performed by point score models.
Authors:
Luca Ceriani; Sergio Suriano; Teresa Ruberto; Emanuele Zucca; Luca Giovanella
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical nuclear medicine     Volume:  37     ISSN:  1536-0229     ISO Abbreviation:  Clin Nucl Med     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7611109     Medline TA:  Clin Nucl Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  949-52     Citation Subset:  IM    
Affiliation:
From the Departments of *Nuclear Medicine and PET/CT Centre and †Medical Oncology, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.
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