| 18F-FDG PET versus CT for the detection of enteropathy-associated T-cell lymphoma in refractory celiac disease. | |
| | |
MedLine Citation:
|
PMID: 17015897 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Refractory celiac disease (RCD) can evolve into enteropathy-associated T-cell lymphoma (EATL). 18F-FDG PET has been reported to discriminate between RCD and EATL. Because prospective data are lacking, we designed a prospective study to evaluate the potential of 18F-FDG PET for detection of EATL in patients with RCD and compared the results with those obtained using abdominal CT in a referral center. METHODS: Between April 2003 and April 2005, 8 consecutive patients (median age, 66 y; range, 52-89 y) with EATL and 30 patients (median age, 61 y; range, 44-71 y) with RCD were included. CT and 18F-FDG PET were performed on all patients. Histologic evidence of EATL was identified in tissue samples obtained during upper gastrointestinal endoscopy or surgical resection. RESULTS: Villous atrophy was found in all patients with RCD and all (except 1) patients with EATL in nontumoral mucosa. Histologic examination of 1 patient with EATL localized in the duodenum showed intraepithelial lymphocytosis only. 18F-FDG PET could reveal sites histologically proven to be EATL in all 8 patients, whereas CT showed normal findings in 1 patient with EATL. 18F-FDG PET detected unsuspected extraintestinal sites affected by EATL in 2 patients. CT showed abnormalities such as a thickened small-bowel wall or lymphadenopathy in 14 patients with RCD lacking evidence of EATL at follow-up. 18F-FDG PET findings were positive in 3 and equivocal in another 3 patients with RCD. 18F-FDG PET was more sensitive and specific than CT (100% vs. 87% and 90% vs. 53%, respectively). CONCLUSION: Our data show that 18F-FDG PET is more sensitive in detecting EATL in patients with RCD than is CT. 18F-FDG PET, in addition to conventional CT, is recommended for evaluating patients with RCD. |
| | |
Authors:
|
Muhammed Hadithi; Maarten Mallant; Joost Oudejans; Jan-Hein T M van Waesberghe; Chris J Mulder; Emile F I Comans |
Related Documents
:
|
16306037 - Combining bronchoscopy and positron emission tomography for the diagnosis of the small ... 1243567 - Screening for bone metastases. are only scans necessary? 9169717 - Necrotizing fasciitis: ct characteristics. 104597 - Prospective comparison of ultrasound and computed tomography in the evaluation of gynec... 8675357 - Low dose megestrol increases serum albumin in malnourished dialysis patients. 9002527 - Characterization of proteinuria in primary glomerulonephritides. sds-page patterns: cli... |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Journal of nuclear medicine : official publication, Society of Nuclear Medicine Volume: 47 ISSN: 0161-5505 ISO Abbreviation: J. Nucl. Med. Publication Date: 2006 Oct |
Date Detail:
|
Created Date: 2006-10-03 Completed Date: 2006-12-22 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0217410 Medline TA: J Nucl Med Country: United States |
Other Details:
|
Languages: eng Pagination: 1622-7 Citation Subset: IM |
Affiliation:
|
Department of Gastroenterology, VU University Medical Center, Amsterdam, The Netherlands. m.hadithi@vumc.nl |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Aged, 80 and over Atrophy Celiac Disease / complications* Duodenum / pathology, radiography, radionuclide imaging Female Fluorodeoxyglucose F18 / diagnostic use* Humans Intestinal Mucosa / pathology, radiography, radionuclide imaging Intestinal Neoplasms / etiology, radiography, radionuclide imaging* Longitudinal Studies Lymphatic Diseases / etiology, radiography, radionuclide imaging Lymphoma, T-Cell / etiology, radiography, radionuclide imaging* Male Middle Aged Positron-Emission Tomography Radiography, Abdominal Radiopharmaceuticals / diagnostic use* Sensitivity and Specificity Tomography, Emission-Computed / methods |
| Chemical | |
Reg. No./Substance:
|
0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Kinetic analysis of 3'-deoxy-3'-18F-fluorothymidine in patients with gliomas.
Next Document: 18F-FDG PET/CT of thymic epithelial tumors: usefulness for distinguishing and staging tumor subgroup...