| 18F-FDG PET for the lymph node staging of non-small cell lung cancer in a tuberculosis-endemic country: is dual time point imaging worth the effort? | |
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MedLine Citation:
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PMID: 18283453 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: This study was to compare (18)F-FDG positron emission tomography (PET) with thoracic contrast-enhanced CT (CECT) in the ability of lymph node (LN) staging non-small cell lung cancer (NSCLC) in a tuberculosis-prevalent country. The usefulness of dual time point PET imaging (DTPI) in NSCLC nodal staging was also evaluated. METHODS: We reviewed 96 NSCLC patients (mean age, 65.3+/-11.7 years) who had received PET studies before their surgery. DTPI were performed on 37 patients (mean age, 64.8+/-12.2 years) who received an additional scan of thorax 3 h after tracer injection. The accuracies of nodal staging by CECT and PET were evaluated according to final histopathology of hilar and mediastinal LN resected by surgery. RESULTS: The accuracy for nodal staging by CECT was 65.6% and that by PET was 82.3% (p<0.05). Six patients were over-staged and 11 were under-staged by PET. Tuberculosis (n=3, 50%) were mostly responsible for false-positive, while small tumor foci (n=7, 63.6%) were mostly accountable for false-negative. For the 37 patients with DTPI, 45 min standardized uptake value (SUV) and 3 h SUV for negative LNs are significantly lower than those for positive LNs (p<0.0001). Nevertheless, the retention index (RI) showed no significant difference between these two groups. CONCLUSIONS: Our study demonstrates that PET is more accurate than CECT in LN staging NSCLC patients in Taiwan where TB is still prevalent. Semi-quantitative SUV method or DTPI with RI does not result in better diagnostic accuracy than visual analysis of PET images. |
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Authors:
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Ruoh-Fang Yen; Ke-Cheng Chen; Jang-Ming Lee; Yeun-Chung Chang; Jane Wang; Mei-Fang Cheng; Yen-Wen Wu; Yung-Chie Lee |
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Publication Detail:
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Type: Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't Date: 2008-02-19 |
Journal Detail:
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Title: European journal of nuclear medicine and molecular imaging Volume: 35 ISSN: 1619-7070 ISO Abbreviation: Eur. J. Nucl. Med. Mol. Imaging Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-06-13 Completed Date: 2008-12-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101140988 Medline TA: Eur J Nucl Med Mol Imaging Country: Germany |
Other Details:
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Languages: eng Pagination: 1305-15 Citation Subset: IM |
Affiliation:
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Department of Nuclear Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Carcinoma, Non-Small-Cell Lung / complications, radionuclide imaging*, secondary* False Positive Reactions Female Fluorodeoxyglucose F18 / diagnostic use* Humans Lung Neoplasms / complications, radionuclide imaging* Lymphatic Metastasis / radionuclide imaging* Male Middle Aged Neoplasm Staging / methods Positron-Emission Tomography / methods* Radiopharmaceuticals / diagnostic use Taiwan Tomography, X-Ray Computed Tuberculosis, Pulmonary / complications |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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