| (18)F-DG PET/CT in detection of recurrence and metastasis of colorectal cancer. | |
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MedLine Citation:
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PMID: 17854148 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To evaluate the value of (18)F-DG PET/CT in detecting recurrence and/or metastasis of colorectal cancer (CRC). METHODS: Combined visual analysis with semiquantitative analysis, the (18)F-DG PET/CT whole-body imaging results and the corresponding clinical data of 68 postoperative CRC patients including 48 male and 20 female with average age of 58.1 were analyzed retrospectively. RESULTS: Recurrence and/or metastasis were confirmed in 56 patients in the clinical follow-up after the PET/CT imaging. The sensitivity of PET/CT diagnosis of CRC recurrence and/or metastasis was 94.6%, and the specificity was 83.3%. The positive predictive value (PPV) was 96.4% and the negative predictive value (NPV) was 76.9%. PET/CT imaging detected one or more occult malignant lesions in 8 cases where abdominal/pelvic CT and/or ultrasonography showed negative findings, and also detected more lesions than CT or ultrasonography did in 30.4% (17/56) cases. Recurrence and/or metastasis was detected in 91.7% (22/24) cases with elevated serum CEA levels by (18)F-DG PET/CT imaging. CONCLUSION: (18)F-DG PET/CT could detect the recurrence and/or metastasis of CRC with high sensitivity and specificity. |
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Authors:
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Long-Bang Chen; Jin-Long Tong; Hai-Zhu Song; Hong Zhu; Yu-Cai Wang |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: World journal of gastroenterology : WJG Volume: 13 ISSN: 1007-9327 ISO Abbreviation: World J. Gastroenterol. Publication Date: 2007 Oct |
Date Detail:
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Created Date: 2007-09-14 Completed Date: 2007-11-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883448 Medline TA: World J Gastroenterol Country: China |
Other Details:
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Languages: eng Pagination: 5025-9 Citation Subset: IM |
Affiliation:
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Department of Medical Oncology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, Jiangsu Province, China. chen.lb@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Carcinoembryonic Antigen / blood Colorectal Neoplasms / pathology, radiography, radionuclide imaging* Female Fluorodeoxyglucose F18 / diagnostic use Humans Male Middle Aged Neoplasm Metastasis / pathology, radiography, radionuclide imaging* Neoplasm Recurrence, Local / pathology, radiography, radionuclide imaging* Positron-Emission Tomography Radiopharmaceuticals / diagnostic use Retrospective Studies Tomography, X-Ray Computed |
| Chemical | |
Reg. No./Substance:
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0/Carcinoembryonic Antigen; 0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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