| 188Rhenium(V)-dimercaptosuccinic acid loaded poly(lactic-co-glycolic)acid microspheres for targeted radiotherapy: production and effectivity. | |
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MedLine Citation:
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PMID: 16124400 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Poly(lactic-co glycolic)acid (75:25) (PLGA) microspheres for the delivery of a radiation dose to tumors were synthesized after loading the 188Re(V) labeled DMSA. The 188ReO4- in place of 99mTcO4- was replaced to label DMSA, because of their structural and chemical similarities and to make the molecule site specific for radiotherapy. The radiolabeling efficiency of DMSA was more than 97% as confirmed by ITLC. A solvent evaporation technique was used to encapsulate DMSA in PLGA microspheres. Electron microscopy demonstrated the microspheres size ranged between 0.4-1.8 microm. As demonstrated by DSC, DMSA was encapsulated (20-30%) within the microspheres in solid solution, metastable molecular dispersion or crystallization forms. In vitro release studies confirmed the stability of DMSA. |
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Authors:
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J Shukla; G P Bandopadhyaya; I K Varma |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Die Pharmazie Volume: 60 ISSN: 0031-7144 ISO Abbreviation: Pharmazie Publication Date: 2005 Aug |
Date Detail:
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Created Date: 2005-08-29 Completed Date: 2005-09-19 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9800766 Medline TA: Pharmazie Country: Germany |
Other Details:
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Languages: eng Pagination: 583-7 Citation Subset: IM |
Affiliation:
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Department of Nuclear Medicine, All India Institute of Medical Sciences, Ansari Nagar, N. Delhi, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Calorimetry, Differential Scanning Chemistry, Physical Excipients Lactic Acid Microscopy, Electron Microspheres Organometallic Compounds / chemistry* Physicochemical Phenomena Polyglycolic Acid Polymers Radioisotopes Radiopharmaceuticals / chemistry* Radiotherapy* Rhenium Spectrophotometry, Infrared Succimer / chemistry* Technetium Tc 99m Dimercaptosuccinic Acid |
| Chemical | |
Reg. No./Substance:
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0/Excipients; 0/Organometallic Compounds; 0/Polymers; 0/Radioisotopes; 0/Radiopharmaceuticals; 0/polylactic acid-polyglycolic acid copolymer; 133466-85-0/rhenium(V)dimercaptosuccinic acid; 26009-03-0/Polyglycolic Acid; 304-55-2/Succimer; 50-21-5/Lactic Acid; 65438-08-6/Technetium Tc 99m Dimercaptosuccinic Acid; 7440-15-5/Rhenium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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