Document Detail


1,8-Naphthyridine-2,7-diamine: a potential universal reader of Watson-Crick base pairs for DNA sequencing by electron tunneling.
MedLine Citation:
PMID:  23038027     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
With the aid of Density Functional Theory (DFT), we designed 1,8-naphthyridine-2,7-diamine as a recognition molecule to read DNA base pairs for genomic sequencing by electron tunneling. NMR studies show that it can form stable triplets with both A : T and G : C base pairs through hydrogen bonding. Our results suggest that the naphthyridine molecule should be able to function as a universal base pair reader in a tunneling gap, generating distinguishable signatures under electrical bias for each of DNA base pairs.
Authors:
Feng Liang; Stuart Lindsay; Peiming Zhang
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Organic & biomolecular chemistry     Volume:  10     ISSN:  1477-0539     ISO Abbreviation:  Org. Biomol. Chem.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-17     Completed Date:  2013-04-05     Revised Date:  2013-08-27    
Medline Journal Info:
Nlm Unique ID:  101154995     Medline TA:  Org Biomol Chem     Country:  England    
Other Details:
Languages:  eng     Pagination:  8654-9     Citation Subset:  IM    
Affiliation:
Center for Single Molecule Biophysics, The Biodesign Institute, Arizona State University, Tempe, Arizona 85287, USA.
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MeSH Terms
Descriptor/Qualifier:
Base Pairing
DNA / chemistry*,  genetics
Diamines / chemical synthesis,  chemistry*
Hydrogen Bonding
Naphthyridines / chemical synthesis,  chemistry*
Nuclear Magnetic Resonance, Biomolecular*
Quantum Theory
Sequence Analysis, DNA*
Grant Support
ID/Acronym/Agency:
HG004378/HG/NHGRI NIH HHS; R21 HG004378/HG/NHGRI NIH HHS
Chemical
Reg. No./Substance:
0/1,8-naphthyridine-2,7-diamine; 0/Diamines; 0/Naphthyridines; 9007-49-2/DNA
Comments/Corrections

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