| 18-Month study of intravenous immunoglobulin for treatment of mild Alzheimer disease. | |
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MedLine Citation:
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PMID: 18294736 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intravenous immunoglobulin (IVIg) has been proposed as a potential agent for Alzheimer's disease (AD) immunotherapy because it contains antibodies against beta-amyloid (Abeta). We carried out an open label dose-ranging study in 8 mild AD patients in which IVIg was added to approved AD therapies for 6 months, discontinued, and then resumed for another 9 months. Infusions were generally well-tolerated. Anti-Abeta antibodies in the serum from AD patients increased in proportion to IVIg dose and had a shorter half-life than anti-hepatitis antibodies and total IgG. Plasma Abeta levels increased transiently after each infusion. Cerebrospinal fluid Abeta decreased significantly at 6 months, returned to baseline after washout and decreased again after IVIg was re-administered for an additional 9 months. Mini-mental state scores increased an average of 2.5 points after 6 months, returned to baseline during washout and remained stable during subsequent IVIg treatment. Our findings confirm and extend those obtained by Dodel et al. [Dodel, R.C., Du, Y., Depboylu, C., Hampel, H., Frolich, L., Haag, A., Hemmeter, U., Paulsen, S., Teipel, S.J., Brettschneider, S., Spottke, A., Nolker, C., Moller, H.J., Wei, X., Farlow, M., Sommer, N., Oertel, W.H., 2004. Intravenous immunoglobulins containing antibodies against beta-amyloid for the treatment of Alzheimer's disease. J. Neurol. Neurosurg. Psychiatry 75, 1472-1474] from a 6-month trial of IVIg in 5 AD patients and justify further studies of IVIg for treatment of AD. |
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Authors:
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Norman R Relkin; Paul Szabo; Basia Adamiak; Tuna Burgut; Carmen Monthe; Richard W Lent; Steven Younkin; Linda Younkin; Richard Schiff; Marc E Weksler |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2008-02-21 |
Journal Detail:
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Title: Neurobiology of aging Volume: 30 ISSN: 1558-1497 ISO Abbreviation: Neurobiol. Aging Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-09-18 Completed Date: 2009-12-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8100437 Medline TA: Neurobiol Aging Country: United States |
Other Details:
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Languages: eng Pagination: 1728-36 Citation Subset: IM |
Affiliation:
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Department of Neurology, The Weill Cornell Medical College, New York, NY, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Alzheimer Disease / drug therapy* Amyloid beta-Protein / blood, cerebrospinal fluid, immunology Drug Administration Schedule Enzyme-Linked Immunosorbent Assay / methods Female Follow-Up Studies Humans Immunoglobulins, Intravenous / therapeutic use* Immunologic Factors / therapeutic use* Male Neurologic Examination Peptide Fragments / cerebrospinal fluid Psychiatric Status Rating Scales Severity of Illness Index Statistics, Nonparametric Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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AG-021033/AG/NIA NIH HHS; M01 RR00047/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Amyloid beta-Protein; 0/Immunoglobulins, Intravenous; 0/Immunologic Factors; 0/Peptide Fragments; 0/amyloid beta-protein (1-40); 0/amyloid beta-protein (1-42) |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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