Document Detail


¹⁸Fluoroethyl-L-tyrosine-PET in long-term epilepsy associated glioneuronal tumors.
MedLine Citation:
PMID:  20946127     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
PURPOSE: Long-term epilepsy associated tumors (LEATs) are a frequent cause of drug-resistant partial epilepsy. A reliable tumor diagnosis has an important impact on therapeutic strategies and prognosis in patients with epilepsy, but often is difficult by magnetic resonance imaging (MRI) only. Herein we analyzed a large LEAT cohort investigated by ¹⁸fluoroethyl-L-tyrosine-positron emission tomography (FET-PET).
METHODS: Thirty-six patients with chronic partial epilepsy and a LEAT-suspect MRI lesion were analyzed by FET-PET using visual inspection and quantitative analysis of standard uptake values (SUV). PET results were correlated with clinical and histopathologic data.
RESULTS: FET-PET study was positive in 22 of 36 analyzed lesions and in 14 of 22 histologically verified LEAT lesions. The precise World Health Organization (WHO) tumoral entity was not predicted by FET-PET. Notably, FET uptake correlated strikingly with age at epilepsy onset (p = 0.001). Further correlations were seen for age at surgery (p = 0.007) and gadolinium-contrast enhancement on MRI (p < 0.05).
DISCUSSION: FET-PET is a helpful tool for LEAT diagnosis, particularly when MRI readings are ambiguous. FET uptake, which is likely mediated by the l-amino acid transporter (LAT) family, might indicate a principally important biologic property of certain LEATs, since LAT molecules also are involved in cell growth regulation.
Authors:
Burkhard S Kasper; Tobias Struffert; Ekkehard M Kasper; Torsten Fritscher; Elisabeth Pauli; Daniel Weigel; Frank Kerling; Thilo Hammen; Wolfgang Graf; Torsten Kuwert; Olaf Prante; Bogdan Lorber; Michael Buchfelder; Arnd Doerfler; Stefan Schwab; Hermann Stefan; Rainer Linke
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Publication Detail:
Type:  Journal Article     Date:  2010-10-13
Journal Detail:
Title:  Epilepsia     Volume:  52     ISSN:  1528-1167     ISO Abbreviation:  Epilepsia     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2983306R     Medline TA:  Epilepsia     Country:  United States    
Other Details:
Languages:  eng     Pagination:  35-44     Citation Subset:  IM    
Copyright Information:
Wiley Periodicals, Inc. © 2010 International League Against Epilepsy.
Affiliation:
Department of Neurology, Epilepsy Center, Friedrich-Alexander University Erlangen, Erlangen, Germany. burkhard.kasper@uk-erlangen.de
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