| (18) FDG-positron emission tomography/computed tomography (PET/CT) scanning in thyroid nodules with nondiagnostic cytology. | |
| | |
MedLine Citation:
|
PMID: 21470288 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Objective To assess the role of positron emission tomography/computed tomography (PET/CT) scans with (18) FDG ((18) FDG-PET/CT) in the evaluation of thyroid nodules with nondiagnostic cytology. Subjects and methods Eighty-eight patients with a single euthyroid nodule and repeatedly nondiagnostic ultrasound-guided fine-needle cytology (US-FNC) were enrolled in the present study. Nodules concentrating (18) FDG were considered positive (i.e. suspicious for malignancy). Histological findings were obtained after surgery in all patients. Results None of 41 patients with negative (18) FDG-PET/CT scan had a final histological diagnosis of malignancy (i.e. no false-negative results). Twenty-nine patients with final histological diagnosis of thyroid cancer had positive (18) FDG-PET/CT scan. Eighteen patients with final histological diagnosis of benign lesions (including four with follicular adenomas) also had positive (18) FDG-PET/CT scans. The sensitivity, specificity, accuracy, positive predictive value (PPV) and negative predictive value (NPV) were 100%, 69%, 79%, 62% and 100%, respectively. Conclusions A negative (18) FDG-PET/CT scan accurately excludes malignancy in thyroid nodules with non-diagnostic US-FNC procedures. Histology is still necessary to distinguish benign from malignant disease in (18) FDG-PET/CT-positive nodules, but unnecessary surgery could have been reduced from 88 to 41 cases (46%) in our series. |
| | |
Authors:
|
Luca Giovanella; Sergio Suriano; Marco Maffioli; Luca Ceriani |
Related Documents
:
|
20086698 - Osteochondritis dissecans of the elbow: diagnosis, treatment, and prevention. 11293288 - Langerhans cell histiocytosis: central nervous system involvement treated successfully ... 1517078 - Bone and gallium scans in postradiotherapy osteonecrosis of the jaw. 17554538 - Whole-body imaging of the musculoskeletal system: the value of mr imaging. 11454728 - Escitalopram (s-citalopram) and its metabolites in vitro: cytochromes mediating biotran... 17654728 - Evaluation of optimal echo time for 1h-spectroscopic imaging of brain tumors at 3 tesla. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Clinical endocrinology Volume: 74 ISSN: 1365-2265 ISO Abbreviation: Clin. Endocrinol. (Oxf) Publication Date: 2011 May |
Date Detail:
|
Created Date: 2011-04-07 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0346653 Medline TA: Clin Endocrinol (Oxf) Country: England |
Other Details:
|
Languages: eng Pagination: 644-8 Citation Subset: IM |
Copyright Information:
|
© 2011 Blackwell Publishing Ltd. |
Affiliation:
|
Department of Nuclear Medicine and Thyroid Centre, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland Department of ENT/Head and Neck Surgery, University Hospital, Varese, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Hyperthyroidism-induced left ventricular diastolic dysfunction: implication in hyperthyroidism-relat...
Next Document: Modulation of aldosterone release by epidural analgesia impacts brain natriuretic peptide: a link to...