| 17β-Estradiol regulates gilthead seabream professional phagocyte responses through macrophage activation. | |
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MedLine Citation:
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PMID: 20692288 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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In mammals, estrogens regulate the immune system, either directly or indirectly via several leukocyte types through autocrine/paracrine mechanisms. In the gilthead seabream (Sparus aurata L.) gonad, an intensive remodeling process accompanied by the massive infiltration of acidophilic granulocytes (AG) is partially triggered by 17β-estradiol (E(2)). Once AG infiltrated the gonad, show impaired activities. In this study we first demonstrate that neither testicular nor head-kidney AG express any of the three estrogen receptor (ER) genes (ERa, ERb1 and ERb2) described in the gilthead seabream, while head-kidney macrophages (Mc) and lymphocytes (Ly) constitutively express ERa gene. Moreover, Mc are important in the immune-modulatory role of E(2), as suggested by its ability to induce ERb2 gene expression and up-regulate the expression of genes coding for ERa, ERb1, pro-inflammatory cytokines, chemokines and tissue remodeling molecules. Furthermore, the soluble factors produced by E(2)-treated Mc decreased in head-kidney phagocytes, their phagocytic ability and capacity, while no effects were observed on their reactive oxygen intermediate (ROI) production or their migratory capabilities. However, the role of Ly in the regulation of AG migration and the modulation of phagocytic and ROI production activities triggered by E(2) can not be ruled out, so that further studies are necessary to clarify these issues. |
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Authors:
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S Liarte; E Chaves-Pozo; E Abellán; J Meseguer; V Mulero; A García-Ayala |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-08-12 |
Journal Detail:
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Title: Developmental and comparative immunology Volume: 35 ISSN: 1879-0089 ISO Abbreviation: Dev. Comp. Immunol. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-10-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7708205 Medline TA: Dev Comp Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 19-27 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Cell Biology and Histology, Faculty of Biology, University of Murcia, 30100 Murcia, Spain. sdll1@um.es |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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