| 17beta-Estradiol metabolites affect some regulators of the MCF-7 cell cycle. | |
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MedLine Citation:
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PMID: 9018099 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The activity of p34(cdc2) plays a key role in the regulation of the eukaryotic cell cycle. Another cell cycle associated molecule is PCNA. We investigated the effects of 2-hydroxy-17beta-estradiol, a cell proliferator, and 2-methoxy-17beta-estradiol, a potent inhibitor of cell growth, on the levels and activity of p34(cdc2) and on the levels of PCNA, as well as on protein phosphorylation in MCF-7 cells. 2-Hydroxyestradiol increased p34(cdc2) activity at G1/S and elevated PCNA levels during S-phase. 2-Methoxyestradiol caused unscheduled activation of p34(cdc2) in S-phase and decreased levels of p34(cdc2) and PCNA during G2/M. We conclude that 2-hydroxy- and 2-methoxyestradiol have definite, though different regulatory functions during the cell cycle. |
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Authors:
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M L Lottering; M de Kock; T C Viljoen; C J Grobler; J C Seegers |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cancer letters Volume: 110 ISSN: 0304-3835 ISO Abbreviation: Cancer Lett. Publication Date: 1996 Dec |
Date Detail:
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Created Date: 1997-02-21 Completed Date: 1997-02-21 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 7600053 Medline TA: Cancer Lett Country: IRELAND |
Other Details:
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Languages: eng Pagination: 181-6 Citation Subset: IM |
Affiliation:
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Department of Physiology, Faculty of Medicine, University of Pretoria, South Africa. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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CDC2 Protein Kinase
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metabolism* Estradiol / analogs & derivatives*, pharmacology* Humans Phosphorylation Proliferating Cell Nuclear Antigen / metabolism* S Phase Tumor Cells, Cultured / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Proliferating Cell Nuclear Antigen; 50-28-2/Estradiol; EC 2.7.11.22/CDC2 Protein Kinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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