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17β-ESTRADIOL AND ESTRADIOL FATTY ACYL ESTERS AND ESTROGEN-CONVERTING ENZYME EXPRESSION IN ADIPOSE TISSUE IN OBESE MEN AND WOMEN.
MedLine Citation:
PMID:  24081738     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Context:Obesity is associated with increased circulating 17β-estradiol (E2) but less is known about E2 concentrations in adipose tissue. In addition to E2, adipose tissue synthesizes E2 fatty acyl esters (E2-FAE).Objective:The aim was to compare estrogen concentrations and expression of estrogen-converting enzymes in adipose tissue between severely obese men and women.Design and Setting:Tissue samples were obtained during elective surgery in University Central Hospital in the years 2008-2011.Patients:We studied 14 men and 22 premenopausal women undergoing bariatric surgery and 10 control women operated for non-malignant reasons.Interventions:Paired samples were taken from abdominal subcutaneous and visceral adipose tissue and serum and analyzed for E2 and E2-FAE by fluoroimmunoassay and liquid chromatography-tandem mass spectrometry. mRNA expression of genes was analyzed by qPCR.Results:Compared to men, E2 levels in subcutaneous adipose tissue in obese women were higher, along with higher relative mRNA expressions of steroid sulfatase and 17β-hydroxysteroid dehydrogenases 1, 7, and 12. In men, E2-FAE concentrations in adipose tissue were similar to E2 but in women significantly lower compared to E2. Adipose tissue E2-FAE and serum E2-FAE levels correlated positively in obese subjects. Serum E2 did not significantly correlate with E2 concentration or mRNA expression of genes in adipose tissue in obese men or women.Conclusions:The production of E2 by the large adipose mass was not reflected by increased circulating E2 concentrations in severely obese men or women. However, adipose tissue may contribute to concentrations of serum E2-FAE.
Authors:
Feng Wang; Veera Vihma; Jarkko Soronen; Ursula Turpeinen; Esa Hämäläinen; Hanna Savolainen-Peltonen; Tomi S Mikkola; Jussi Naukkarinen; Kirsi H Pietiläinen; Matti Jauhiainen; Hannele Yki-Järvinen; Matti J Tikkanen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-9-30
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  -     ISSN:  1945-7197     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-10-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
aFolkhälsan Research Center, Biomedicum Helsinki, 00290 Helsinki, Finland.
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